CAS: 88491-61-6; 3-Bromopyridazine

该化合物是一种环环状有机化合物,在3号站点用溴原子取代了一条环,该化合物是有机合成的多用途中间体,特别是在制药和农用化学应用方面,其溴基能产生高效的交叉反应,如Suzuki或Buchwald-Hartwig的交汇,便利复杂的pyridazine衍生物的建造;pyridazine环的电衰变性可增强核生殖器替代反应的再活动性. 3-Bromopyridazine因其在标准条件下的稳定性及其与一系列反应条件的兼容性而受到重视,使它成为医学化学和材料科学研究人员的可靠建筑.

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相似化合物

17973-86-3 1196155-35-7 1353854-35-9

物理性质

MSDS等安全信息

欧盟法规

C&L通报

合成工艺路线路线简述

  • 合成目标产物 Pyridazine, 3-Bromo- (9CI) 主要起始原料 3(2H)-Pyridazinone
  • 215451-50-6 = 88491-61-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Pyridazines By Addition Of Diazoalkanes To 1-Bromo- And 1,2-Dibromocyclopropenes
    作者:Dulayymi,Ahmad R.; Et Al
    参考文献:Tetrahedron 日期:1998 卷标:54(42) 页码:12897-12906]

    108186-05-6 = 88491-61-6
    反应条件:1.1 Solvents: Diethyl Ether1.2 Solvents: Water2.1 Solvents: Chloroform3.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Pyridazines By Addition Of Diazoalkanes To 1-Bromo- And 1,2-Dibromocyclopropenes
    作者:Dulayymi,Ahmad R.; Et Al
    参考文献:Tetrahedron 日期:1998 卷标:54(42) 页码:12897-12906]

    504-30-3 = 88491-61-6
    反应条件:1.1 Reagents: Phosphoric Tribromide Solvents: Acetonitrile; 25 Min,80 °C1.2 Reagents: Sodium Carbonate Solvents: Water; Basified
    标题:Synthesis Of 3-Bromopyridazine
    作者:Hong,Dong-Feng; Et Al
    参考文献:Yingyong Huagong 日期:2012 卷标:41(9) 页码:1645-1647]

    215451-47-1 = 88491-61-6 [标题:Reaction Conditions
    标题:Product Class 8: Pyridazines
    作者:Haider,N.; Et Al
    参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:125-249]

    215451-47-1 = 88491-61-6
    反应条件:1.1 Solvents: Chloroform2.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Pyridazines By Addition Of Diazoalkanes To 1-Bromo- And 1,2-Dibromocyclopropenes
    作者:Dulayymi,Ahmad R.; Et Al
    参考文献:Tetrahedron 日期:1998 卷标:54(42) 页码:12897-12906]

    19064-67-6 = 88491-61-6
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Catalysts: Palladium Solvents: Ethanol; 6 H,1.5 - 2 Mpa,Rt -> 80 °C2.1 Reagents: Phosphoric Tribromide Solvents: Acetonitrile; 25 Min,80 °C2.2 Reagents: Sodium Carbonate Solvents: Water; Basified
    标题:Synthesis Of 3-Bromopyridazine
    作者:Hong,Dong-Feng; Et Al
    参考文献:Yingyong Huagong 日期:2012 卷标:41(9) 页码:1645-1647]

    141-30-0 = 88491-61-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 90 °C; 6 H,90 °C -> 100 °C; 100 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 32.1 Reagents: Sodium Hydroxide,Hydrogen Catalysts: Palladium Solvents: Ethanol; 6 H,1.5 - 2 Mpa,Rt -> 80 °C3.1 Reagents: Phosphoric Tribromide Solvents: Acetonitrile; 25 Min,80 °C3.2 Reagents: Sodium Carbonate Solvents: Water; Basified
    标题:Synthesis Of 3-Bromopyridazine
    作者:Hong,Dong-Feng; Et Al
    参考文献:Yingyong Huagong 日期:2012 卷标:41(9) 页码:1645-1647
📜3-哒嗪酮置于三溴氧磷体系中,化学反应 3.0H,以69%的收率获得产物3-溴哒嗪
参考文献: 3-Oxo-Tetrahydro-Furo[3,2-B]Pyrrol-4(5H)-yl) Derivatives Ii[fr] Dérivés Ii Du 3-Oxo-Tétrahydro-Furo[3,2-B]Pyrrol-4(5H)-Yle
标题: 3-Oxo-Tetrahydro-Furo[3,2-B]Pyrrol-4(5H)-yl) Derivatives Ii[fr] Dérivés Ii Du 3-Oxo-Tétrahydro-Furo[3,2-B]Pyrrol-4(5H)-Yle
摘要:这项发明涉及作为双重cats/k抑制剂的酰胺氧代四氢-2H-呋喃[3.2-B]吡咯-4(5H)-基)衍生物,这些衍生物表现出明显的catk抑制作用,以及含有这些化合物的药物组合物,以及这些化合物用于治疗和/或预防疼痛和其他疾病和/或紊乱.

专利信息


专利号:US-4171438-A
优先权日:1975-07-23
标 题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：DOUGLAS JAMES L; HORNING DONALD E; MORRIS LEESON R
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is acylamino and Z represents optionally substituted C1-C6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-12152038-B2
优先权日:2017-09-05
标 题:Vasopressin receptor antagonists and products and methods related thereto
发明人：JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; CHAMBERS MARK; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON; LOCK CHRIS
权利人:NEUMORA THERAPEUTICS INC
摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein Q1, Q2, Q3, R2a, R2b, R3 and X are as defined herein.

专利号:CN-118955404-A
优先权日:2024-07-30
标题:Synthesis method of compound 3, 5-dibromopyridazine

专利号:CN-115557900-B
优先权日:2022-11-11
标 题:Synthesis method of 3-substituted pyridazine derivative

专利号:CN-112300057-B
优先权日:2020-10-19
标 题 :A kind of D-A-D hole transport material and its synthesis method and application

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合成参考文献


摘要:Haider, N.; Holzer, W., Science of Synthesis, (2004) 16, 153.
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