CAS: 779-89-5; 3-(3-(Trifluoromethyl)Phenyl)Acrylic Acid

上下游产品

piperidine 3-Trifluoromethylbenzaldehyde malonic acid acetic anhydride (E)-N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-trifluoromethyl-phenyl)-acrylamide (E)-4-(3-trifluoromethylphenyl)but-3-en-2-one trans-3-(trifluoromethyl)cinnamoyl chloride trans-methyl 3-(3-(trifluoromethyl)phenyl)acrylate

Ethyl (E)-3-(3-(Trifluoromethyl)Phenyl)Acrylate置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,以90 %的收率获得产物3-三氟甲基肉桂酸
参考文献:用于 Mizoroki-Heck 反应的负载钯陶瓷催化膜反应器
标题:用于 Mizoroki-Heck 反应的负载钯陶瓷催化膜反应器
摘要:通用高效的负载钯陶瓷催化膜反应器首次被报道应用于mizoroki-Heck反应.所制备的催化膜 Pd-Kh792-Cm 在流通式 Mizoroki-Heck 反应中表现出高活性和选择性.催化膜在五个循环中持续的高活性也证明了其非常好的稳定性和可回收性.药物分子的合成进一步证明催化膜方案是传统 Mizoroki-Heck 交叉偶联的强大而全面的替代方案.
DOI:10.1055/a-2119-5236

专利信息

专利号:US-2010267988-A1
优先权日:2006-06-08
标 题:Processes for preparing intermediate compounds useful for the preparation of cinacalcet
发明人：SZEKERES TIBOR; REPASI JOZSEF; SZABO ANDRAS; MANGION BERNARDINO
权利人:MEDICHEM SA
摘要:The invention relates, in general, to an improved process for preparing compounds (e.g., 3-(3-trifluoromethylphenyl)propanal (Compound III, below)), which are key intermediates for the synthesis of cinacalcet, its salts and/or solvates thereof, as well as the use of such compounds prepared by such process for the preparation of cinacalcet and/or its salts or solvates.

专利号:EP-1990333-A1
优先权日:2007-05-11
标题 :Process for the preparation of cinacalcet hydrochloride
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of cinacalcet hydrochloride which is industrially feasible and commercially viable. The synthesis of cinacalcet hydrochloride is carried out by the condensation of 3-trifluromethylphenyl propionic acid with R-(+)-1-(lnaphthyl)ethylamine.

专利号:US-7361789-B1
优先权日:2004-07-28
标 题 :Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
发明人：YAN QI; ORIHUELA CARLOS; SHEN BO; CHEN YING; WANG XIN; NG JOHN; JI RUIZHI; ZHOU PENGZU
权利人:AMGEN INC
摘要:The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.