CAS: 737-31-5; Sodium 3,5-Diacetamido-2,4,6-Triiodobenzoate

上下游产品

diatrizoic acidPropanedioic acid, [[3,5-bis(acetylamino)-2,4,6-triiodobenzoyl]oxy]methyl-bis(1-methylethyl)ester Ethyl (3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)acetate 3,5-diamino-2,4,6-triiodobenzoic acid

泛影酸 在 Sodium Carbonate体系中,用 水作为反应溶剂,获得 Sodium Diatrizoate
参考文献:从无水,水合和溶剂化的泛影酸结晶形式的结晶过程的见解
标题:从无水,水合和溶剂化的泛影酸结晶形式的结晶过程的见解
摘要:Diadiazoic Acid(Dta),一种临床上使用的x射线造影剂,以两种水合,三种无水和九种溶剂化的固体形式结晶,所有这些都通过x射线晶体学进行了表征.已确定dta二水合物和dta四水一钠的单晶中子结构.所有的固态结构均已使用部分原子电荷和硬度算法(Pacha)计算进行了分析.即使通常所有dta晶体形式都表现出相似的分子间相互作用,但晶体的整体堆积因形式而异.二水合物的水被封装在一对宿主分子之间,计算表明这是一个非常稳定的基序.Dta提供了可实现氢键和卤素键的功能,尽管在所有晶形中都实现了扩展的氢键网络,但在水合晶形中不存在卤素键.这是由于基于单个封闭的水方块形成了氢键网络,因此不伴有卤素键的形成.溶剂化物中的主要相互作用涉及羧酸,这证实了这种强相互作用是在晶体去溶剂化和成核过程中最后一个被打破的假设.
Doi:10.1002/Chem.201404693

专利信息

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-5948693-A
优先权日:1994-09-01
标题:Solid phase synthesis of immunosuppressive agents
发明人：RICH DANIEL H; RAMAN PRAKASH; ANGELL YVONNE M
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention relates generally to cyclosporin analogs, and more paritcularly to methods for the solid-phase synthesis and on-resin cyclization of cyclosporin analogs. Methods are described for the on-resin cyclization of sterically hindered compounds synthesized through solid phase synthesis techniques. The methods utilize solvent, temperature, and washing conditions that allow the efficient on-resin cyclization of compounds like analogs of cyclosporin A.

专利号:US-5320943-A
优先权日:1991-03-29
标题 :Methods of detecting T-cell dysfunctions
发明人：FUKUDA MINORU
权利人:JOLLA CANCER RES FOUND
摘要:A method is provided for detecting T-cell dysfunctions. The method includes detecting an alteration in the level of a protein regulating synthesis of the hexasaccharide NeuNAc alpha 2->3Gal beta 1->3(NeuNAc alpha 2->3Gal beta 1->4GlcNAc beta 1->6)GalNAc on leukosialin of T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. The protein regulating synthesis of the hexasaccharide can be core 2 GlcNAc transferase and can be detected by either a change in its amount or activity. Also provided is a method of detecting T-cell dysfunctions which includes detecting an alteration in the level of leukosialin having the hexasaccharide NeuNAc alpha 2->3Gal beta 1->3(NeuNAc alpha 2->3Gal beta 1->4GlcNAc beta 1->6)GlcNAc on T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. Kits for detecting T-cell dysfunction are provided as well.

专利号:US-6238875-B1
优先权日:1991-03-12
标题:Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1
发明人：ALTIERI DARIO C
权利人:SCRIPPS RESEARCH INST
摘要:A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. These new cell surface receptors are designated effector cell protease receptors (EPRs) and include EPR-1, which is shown to bind protease ligands. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention. n Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The receptors are also demonstrated to bind coagulation factor Xa, which binding is inhibited by various disclosed monoclonal antibodies to the receptors. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.

专利号:US-2019054057-A1
优先权日:2016-03-08
标题 :Immune boosting dietary compounds for disease control and prevention
发明人：ZHANG GUOLONG
权利人:THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIV OFFICE OF INTELLECTUAL PROPERTY MANAGEMENT
摘要:Provided herein are small-molecule compounds and combinations thereof that enhance the synthesis of animal endogenous genus host defense peptides, which display potent antimicrobial and immunomodulatory activities. They thus represent alternatives to antibiotics for disease control and prevention for use in animals and humans. Examples of the small molecule compounds include histone deacetylase inhibitors, mono- and disaccharide sugars, cyclic adenosine monophosphate (cAMP) signaling agonists, and cyclooxygenase -2 (COX-2) inhibitors. Synergistic combinations include short-chain fatty acids, their chemical analogs or histone deacetylase inhibitors with other fatty acids, sugars, cAMP signaling agonists, and/or COX-2 inhibitors.