CAS: 674-81-7; 2-Nitrosoguanidine

该化合物是一种化学化合物,属于硝胺类,以其潜在的致癌特性而著称;它是在水和有机溶剂中溶解的无色黄色的浅色液体;该化合物的特征是附于一个瓜尼丁结构的硝酸盐组(-N=O),该组有助于其再活性;N-Nitrosoguanidine主要用于各种用途的实验室环境,包括基因研究中的诱变剂和有机合成中的试剂;由于它能够诱发DNA中的突变,因此已对其对活生物体的影响进行了广泛研究,特别是在癌症研究方面;然而,由于它的毒性和致癌性质,需要谨慎地处理和处置,因此对它的使用进行了规范.总的来说,N-硝基瓜尼作为生物化学和分子生物学中的一个重要工具,同时强调在与危险物质打交道时需要安全防范.

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CAS号556-88-7 硝基胍 | CAS号593-85-1 碳酸胍 | CAS号7632-00-0 亚硝酸钠 | CAS号7664-93-9 硫酸 | CAS号556-88-7 硝基胍 | CAS号420-04-2 氰胺 | CAS号124-38-9 二氧化碳 | CAS号7664-41-7 氨 | CAS号79-17-4 氨基胍盐酸盐 | CAS号6882-47-9 2-(diaminomethy... | CAS号108-78-1 三聚氰胺 | CAS号645-93-2 三聚氰胺一酰胺 | CAS号113-00-8 guanidine | CAS号645-92-1 三聚氰酸二酰胺

合成工艺路线路线简述

    📜碳酸胍置于硫酸,Sodium Nitrite体系中,化学反应生成 亚硝基胍
    参考文献:Pellizzari,Gazzetta Chimica Italiana,1921,Vol. 51 I,P. 226 Anm.
    标题:Pellizzari,Gazzetta Chimica Italiana,1921,Vol. 51 I,P. 226 Anm.

    专利信息


    专利号:US-2008287407-A1
    优先权日:2003-12-10
    标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
    发明人:GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
    权利人:NITROMED INC
    摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

    专利号:US-12215369-B2
    优先权日:2019-03-01
    标题:Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
    发明人:ALEXANDRINO PAULO MOISES RADUAN; GOUVEA IURI ESTRADA; QUEIROZ VERONICA LEITE
    权利人:BRASKEM SA
    摘要:The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.

    专利号:US-8809023-B2
    优先权日:2009-08-19
    标题 :Variants of glucoamylase
    发明人:DEGN PETER EDVARD; BOTT RICHARD; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG
    权利人:DEGN PETER EDVARD; BOTT RICHARD; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; DANISCO US INC
    摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

    专利号:WO-8605515-A1
    优先权日:1985-03-18
    标 题:In vitro synthesis of l-tryptophan
    发明人:HSIAO HUMG-YU; WEI TENA T; ANDERSON DAVID M
    权利人:GENEX CORP
    摘要:A method of synthesizing L-tryptophan from glycine, formaldehyde and indole using biocatalytic amounts of serine hydroxymethyltransferase, tetrahydrofolic acid and tryptophan synthetase or tryptophanase. The serine hydroxymethyltransferase and tryptophan synthetase or tryptophanase are preferably provided to the reaction medium in the form of expression products of transformed microorganisms containing expression vectors coding for serine hydroxymethyltransferase and tryptothan synthetase or tryptophanase.

    专利号:US-5559015-A
    优先权日:1986-03-26
    标 题:Recombinant-DNA mediated production of xanthan gum
    发明人:CAPAGE MICHAEL A; DOHERTY DANIEL H; BETLACH MICHAEL; VANDERSLICE REBECCA W
    权利人:GETTY SCIENT DEV CO
    摘要:Methods for the recombinant-DNA mediated production of xanthan gum and gum variants structurally related to xanthan are disclosed. The methods in part involve the synthesis of these polysaccharides in anaerobic and/or denitrifying hosts. In particular, plasmids pX209 and pRK290-H366 are disclosed which contain the genes, isolated from X. campestris, encoding Transferase I, Transferases II, Transferase III, Transferase IV, Transferase V, Ketalase, Acetylase and Polymerase. These plasmids have been deposited in the American Type Culture Collection under Accession Nos. 67051 and 67049, respectively.

    专利号:US-8541191-B2
    优先权日:2008-08-29
    标 题 :Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids
    发明人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R
    权利人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R; BUNGE OILS INC
    摘要:Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.

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    合成参考文献


    参考文献:10.2174/1874285801105010043
    摘要:Roy S, Anand D, Vijay S, Gupta P, Ajitkumar P. The ftsZ Gene of Mycobacterium smegmatis is expressed Through Multiple Transcripts. Open Microbiol J. 2011;5():43–53.
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