CAS: 646-06-0; 1,3-Dioxolane

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CAS号201230-82-2 carbon monoxide | CAS号75-07-0 乙醛 | CAS号4544-20-1 2-乙氧基-1,3-二氧戊环 | CAS号107-21-1 乙二醇 | CAS号50-00-0 甲醛 | CAS号1124-68-1 (CH2CH2O2)B(O-n... | CAS号118685-83-9 2-(3-methyl-but... | CAS号75-21-8 环氧乙烷 | CAS号19693-75-5 2-甲氧基-1,3-二氧戊环 | CAS号109620-95-3 4-methoxy-1,3-d... | CAS号149-73-5 原甲酸三甲酯 | CAS号5470-70-2 6-甲基烟酸甲酯 | CAS号69971-44-4 4,6-二甲基烟酸甲酯 | CAS号542-88-1 二氯甲基醚 | CAS号1462-33-5 2-氯乙基氯甲基醚 | CAS号111-44-4 二氯乙基醚 | CAS号74-87-3 氯甲烷 | CAS号1487-43-0 2-chloroethyl f...

乙醛 以 甲苯 作为反应溶剂,以69%的收率获得产物1,3-二氧戊环
参考文献:Prostaglandin Analogs
标题:Prostaglandin Analogs
摘要:血栓素受体拮抗活性由以下式的化合物展示:##str1## 其中:V为--(Ch.Sub.2).Sub.M--,--O--,或##str2## 但如果v为--O--或##str3##,则r.Sup.3和r.Sup.4必须形成一个芳香环;w为--(Ch.Sub.2).Sub.2--,--Ch.Dbd.Ch--或苯基;x为单键,--Ch.Dbd.Ch--,--(Ch.Sub.2).Sub.N--,或--O--(Ch.Sub.2).Sub.N--;或x为支链烷基或--O--支链烷基,其中w通过一个含有n个碳原子的链连接到y;y为--Co.Sub.2 H,--Co.Sub.2 烷基,--Co.Sub.2 碱金属,--Ch.Sub.2 Oh,--Conhso.Sub.2 R.Sup.5,--Conhr.Sup.6,或--Ch.Sub.2-5-四唑基;z为o或nh;r.Sup.3和r.Sup.4分别独立地为氢或烷基,或r.Sup.3和r.Sup.4一起形成一个环,该环可以通过一个含有卤素,低烷基,苯基,卤代(低烷基),卤代苯基,氧代或羟基基团的环碳原子进行选择性取代;其余符号如规范中定义.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-9506095-B2
优先权日:2012-02-09
标 题:Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof
发明人：PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the enzymatic synthesis of the compound of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl group.n n Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-8084007-B2
优先权日:2004-01-30
标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes
发明人：SPIELVOGEL BERNARD; COOK KEVIN S
权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC
摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.