CAS: 6315-52-2; Ethane-1,2-Diyl Bis(4-Methylbenzenesulfonate)

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CAS号107-21-1 乙二醇 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号4124-41-8 对甲苯磺酸酐 | CAS号54509-73-8 ethene | CAS号108164-35-8 hydroxy(perfluo... | CAS号16836-95-6 对甲苯磺酸银 | CAS号106-93-4 1,2-二溴乙烷 | CAS号6192-52-5 对甲苯磺酸一水合物 | CAS号75-21-8 环氧乙烷 | CAS号383-50-6 对甲苯磺酸氟乙酯 | CAS号52667-88-6 1,4,7,10-四甲苯磺酰-... | CAS号53408-96-1 4-硝基苯-18-冠-6 | CAS号22846-16-8 1-phenylphosphirane | CAS号107-21-1 乙二醇 | CAS号22308-12-9 1,3-双(甲苯磺酰氧基)-2... | CAS号624-72-6 1,2-二氟乙烷 | CAS号104-66-5 1,2-二苯氧乙烷 | CAS号6052-10-4 1,2-双(4-氨基苯氧基)乙烷 | CAS号136779-26-5 1,2-双[(2S,5S)-2...

乙二醇 以 吡啶 作为反应溶剂,化学反应生成 1,2-双甲苯氧基乙烷
参考文献:Elimination And Substitution In The Reactions Of Vicinal Dihalides And Oxyhalides Trimethylstanoylsodium. Effects Of Solvent And Of Ion Aggregation On Course And Stereochemistry
标题:Elimination And Substitution In The Reactions Of Vicinal Dihalides And Oxyhalides Trimethylstanoylsodium. Effects Of Solvent And Of Ion Aggregation On Course And Stereochemistry
摘要:
DOI:10.1021/jo00394A007

专利信息

专利号:US-8058414-B2
优先权日:2008-04-29
标题 :Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
发明人：MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI
权利人:MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI; LIFE TECHNOLOGIES CORP
摘要:Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.

专利号:US-9085518-B2
优先权日:2011-10-14
标题 :Method for the synthesis of 18F-labelled molecules
发明人：NAIRNE ROBERT JAMES DOMETT; BHALLA RAJIV; KHAN IMTIAZ; BROWN JANE; WILSON ANTHONY; BLACK ANDRES
权利人:GE HEALTHCARE LTD
摘要:The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

专利号:US-9125954-B2
优先权日:2011-10-14
标 题 :Method for the synthesis of 18F-labelled biomolecules
发明人：BHALLA RAJIV; WILSON ANTHONY; KHAN IMTIAZ; BROWN JANNE
权利人:GE HEALTHCARE LTD
摘要:The present invention provides a method for the synthesis of 18 F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

专利号:US-2024400533-A1
优先权日:2023-06-02
标题 :General Solid-Phase Synthesis of Crown Ethers
发明人：TRANT JOHN F; NASRI SARAH; HAYWARD JOHN J
权利人:UNIV OF WINDSOR
摘要:In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.

专利号:US-5498734-A
优先权日:1991-09-23
标 题:Preparation and use of (2-butene-1,4-diyl)magnesium complexes in organic synthesis
发明人：RIEKE REUBEN D
权利人:UNIV NEBRASKA
摘要:The magnesium complexes of cyclic hydrocarbons containing conjugated dienes, such as 1,2-dimethylenecycloalkanes, and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4 diyl)magnesium reagents with electrophiles such as dibromoalkanes, alkylditosylates, alkylditriflates, bromoalkylnitriles, esters, or amides serve as a convenient method for synthesizing carbocyclic systems. Significantly, carbocycles prepared by this method contain functional groups such as the exocyclic double bond or a keto group in one of the rings which could be used for further elaboration of these molecules. Furthermore, fused bicyclic systems containing a substituted five-membered ring can be conveniently prepared at high temperatures by the reactions of (2-butene-1,4-diyl)magnesium complexes with carboxylic esters or acid halides whereas low temperatures lead to regioselective synthesis of β,γ-unsaturated ketones. Additionally, γ-lactones, including spiro γ-lactones, can be easily prepared in a one pot synthesis from the reaction of (2-butene-1,4-diyl)magnesium complexes with a ketone or aldehyde and carbon dioxide. Also, δ-lactones can be easily prepared in a one pot synthesis from the reaction of (2-butene-1,4-diyl)magnesium complexes with epoxides followed by reaction with CO 2 . Use of α-hydroxy epoxides without the addition of CO 2 leads to the synthesis of vicinal diols. Chiral epoxides lead to chiral alcohols.

专利号:US-2012189547-A1
优先权日:2009-10-08
标 题 :[18f] labelled analogues of flumazenil as in vivo imaging agents
发明人：WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
权利人:WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
摘要:The present invention provides radiofluorinated compounds useful for in vivo imaging GABA A receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.