CAS: 627-91-8; Monomethyl Adipate

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141-28-6 626-86-8 627-93-0

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CAS号627-93-0 己二酸二甲酯 | CAS号67-56-1 甲醇 | CAS号124-04-9 己二酸 | CAS号6654-36-0 6-氧代己酸甲酯 | CAS号120-92-3 环戊酮 | CAS号2979-24-0 2-甲氧基环己醇 | CAS号81158-34-1 2-(4-methoxy-4-... | CAS号81158-33-0 (Z)-4-(methoxyc... | CAS号4547-43-7 6-羟基己酸甲酯 | CAS号457612-06-5 3-(2-amino-5-ch... | CAS号56523-59-2 15-溴十五酸 | CAS号542-28-9 δ-戊内酯 | CAS号35444-44-1 甲基脂肪酰氯 | CAS号5963-14-4 8-甲基壬酸 | CAS号629-11-8 1,6-己二醇 | CAS号4547-43-7 6-羟基己酸甲酯 | CAS号506-33-2 芸香酸 | CAS号4266-66-4 1,8-二氮杂环十四烷-2,7-二酮 | CAS号506-13-8 16-羟基十六烷酸 | CAS号506-30-9 花生酸

6-羟基己酸甲酯置于potassium Hydrogensulfate,2,2,6,6-四甲基哌啶氧化物,Copper(II) Nitrate Trihydrate,氧气体系中,用 1,2-二氯乙烷 作为反应溶剂,以78 %的收率获得产物脂肪酸甲酯
参考文献:铜催化伯醇有氧氧化成羧酸
标题:铜催化伯醇有氧氧化成羧酸
摘要:在这里,开发了第一个以 Tempo 和 Khso 4作为助催化剂的铜催化伯醇有氧氧化成羧酸的反应.该反应在温和条件下表现出优异的底物范围和官能团相容性.即使是非常敏感的手性醇,手性氨基醇和含醇的类固醇骨架也可以被氧化以提供相应的羧酸或内酯而无需外消旋化.
DOI:10.1039/d3Cc00963G

专利信息

专利号:US-2025162968-A1
优先权日:2022-02-02
标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids
发明人：ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A
权利人:NANOVATION THERAPEUTICS INC
摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.

专利号:US-6723843-B2
优先权日:1996-08-26
标题:Oligosaccharide synthesis
发明人：TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY
权利人:ALCHEMIA PTY LTD
摘要:The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.

专利号:US-6441246-B1
优先权日:1998-08-27
标题:Catalytic synthesis of aldehydes by direct hydrogenation of carboxylic acids
发明人：YAMAMOTO AKIO; NAGAYAMA KAZUHIRO
权利人:JAPAN SCIENCE & TECH CORP
摘要:A process which makes it possible to prepare aldehydes under mild reaction conditions with a high efficiency through the reduction of carboxylic acids with molecular hydrogen. Specifically, a process of reducing an organic carboxylic acid with molecular hydrogen in the presence of a catalyst into an aldehyde corresponding to the acid, characterized by conducting the reduction in the presence of a dehydrating agent such as a carboxylic anhydride.

专利号:WO-8203079-A1
优先权日:1981-03-10
标题 :Rapid solid phase synthesis of oligonucleotides using phosphorus oxychloride activation
发明人：VERLANDER MICHAEL S; FULLER WILLIAM DEAN; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:Method for synthesizing oligonucleotides comprising the steps of filling a flow reactor with a supported nucleoside consisting of a first nucleoside attached in position (5 ') to an insoluble solid support, activating this support nucleoside by a treatment with phosphorus oxychloride in the presence of a basic catalyst in order to form a 3'-dichlorophosphoryl group on the first nucleoside, to couple a second analogous or different nucleoside, unprotected at positions 3 'and 5', to the first nucleoside by condensation with the dichlorophosphoryl group and to repeat this activation and coupling step until the desired oligonucleotide sequence is obtained. The oligonucleotide can then be cleaved from the support and purified, if necessary.

专利号:US-9944579-B2
优先权日:2015-01-15
标题 :Catalytic hydrogenation process for the synthesis of terminal diols from terminal dialkyl aliphatic esters
发明人：BALARAMAN EKAMBARAM; SAHOO MANOJ KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:A phosphorus ligand-free, mild, efficient and complete catalytic hydrogenation process is for the sustainable production of terminal diols from renewable terminal dialkyl esters with improved yield. Soluble, phosphorus ligand free Ru (II)-pincer type complexes can be used as catalysts in the hydrogenation process.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.