CAS: 598-56-1; N,N-Dimethylethylamine

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CAS号127-19-5 N,N-二甲基乙酰胺(DMAC) | CAS号2650-77-3 三甲基乙基溴化铵 | CAS号50-00-0 甲醛 | CAS号75-04-7 乙胺 | CAS号64-17-5 乙醇 | CAS号124-40-3 二甲胺 | CAS号124330-23-0 N,N-二甲基乙胺醛烷络合物 | CAS号64-20-0 四甲基溴化铵 | CAS号926-64-7 (二甲氨基)乙腈 | CAS号317323-77-6 4-(4-氟苯)-1-甲基-3... | CAS号20109-38-0 DIMETHYL DIETHY... | CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号7335-27-5 4-氯苯甲酸乙酯 | CAS号1823-91-2 2-苯丙腈 | CAS号685-91-6 N,N-二乙基乙酰胺 | CAS号38806-26-7 N-乙基-N-甲基乙酰胺 | CAS号69300-15-8 2-甲基癸腈 | CAS号608521-21-7 Paroxol Methane... | CAS号51-93-4 乙基三甲基碘化铵

📜N,N-二甲基乙酰胺置于[mg(1,4,7-Trimethyl-1,4,7,10-Tetraazacyclododecanealibu3)(Thf)][hbph3],频那醇硼烷体系中,用 四氢呋喃,氘代四氢呋喃 作为反应溶剂,化学反应 72.0H,以100%的收率获得产物二甲基十二/十四烷基叔胺
参考文献:具有末端镁-氢键的分子氢化镁的反应性
标题:具有末端镁-氢键的分子氢化镁的反应性
摘要:分子镁氢化物的反应性[镁(me 3 Tacd.铝我卜3)h](1),具有终端镁-氢键和nnnn型大环配位体中,Me 3 Tacd((me 3 Tacd)h = Me 3 [12] Anen 4 = 1,4,7-三甲基-1,4,7,10-四氮杂环十二烷可分为质子分解,氧化,加氢金属化(插入)和氢化物提取.用弱的布朗斯台德酸hx(例如末端乙炔,胺,硅烷醇和硅烷)对1进行质子分解,得到相应的衍生物[mg(me 3 Tacd.al I Bu 3)x](x =c≡cph,3; Hn(3,5-Me 2-C 6 H 3),4 ; Osime 3,5 ; Osiph 3,6 ; Cl,7;br,8).苯胺4的单晶x射线衍射显示镁的正方形-金字塔形配位几何形状.没有检测到与酸的p K A值相关.用元素碘氧化1得到碘化物[mg(me 3 Tacd.al I Bu 3)i](9),然后用一氧化二氮氧化得到μ-氧桥联化合物[{mg(me3
DOI:10.1021/acs.Inorgchem.6B02509

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-2025051339-A1
优先权日:2021-12-15
标题:Methods for the synthesis of complement factor d inhibitors
发明人：HASHIMOTO AKIHIRO
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof. The methods involve subjecting an intermediate in the synthesis of a complement factor D inhibitor to a t-butyl ester deprotection reaction using a weak base.

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-7901664-B2
优先权日:2008-03-31
标题 :Synthesis of aluminophosphate and metalloaluminophosphate molecular sieves
发明人：CAO GUANG; AFEWORKI MOBAE; SHAH MATU J; MERTENS MACHTELD MARIA
权利人:EXXONMOBIL CHEM PATENTS INC
摘要:In a method of synthesizing an aluminophosphate or metalloaluminophosphate molecular sieve, a synthesis mixture is provided comprising water, a source of aluminum, a source of phosphorus, optionally a source of a metal other than aluminum, a tertiary amine, and an alkylating agent capable of reacting with said tertiary amine to form a quaternary ammonium compound capable of directing the synthesis of said molecular sieve. The synthesis mixture is maintained under conditions sufficient to cause the alkylating agent to react with the tertiary amine to produce the quaternary ammonium compound and to induce crystallization of the molecular sieve.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-8426612-B2
优先权日:2009-04-22
标 题:Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole
发明人：SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO
权利人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO; ITALIANA SINT SPA
摘要:The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.