CAS: 585-50-2; 3-(3-(Trifluoromethyl)Phenyl)Propanoic Acid

上下游产品

CAS号779-89-5 间三氟甲基肉桂酸 | CAS号3984-22-3 2-乙烯基-1,3-二氧戊环 | CAS号401-78-5 间溴三氟甲苯 | CAS号294856-02-3 Methyl 3-(3-(tr... | CAS号95096-06-3 3-[3-(三氟甲基)苯基]丙腈 | CAS号454-89-7 间三氟甲基苯甲醛 | CAS号1005450-55-4 盐酸西那卡塞胺化物 | CAS号78573-45-2 3-(3-三氟甲基苯基)丙醇 | CAS号364782-34-3 盐酸西那卡塞 | CAS号1003048-68-7 7-三氟甲基-1-茚酮 | CAS号129254-76-8 1-(3-溴丙基)-3-(三氟甲基)苯 | CAS号226256-56-0 西那卡塞 | CAS号21172-41-8 3-(3-三氟甲基苯基)丙醛 | CAS号221246-34-0 17-TRIFLUOROMET... | CAS号70311-33-0 间三氟甲基苯丙酸乙酯 | CAS号535-53-5 3-(3-(trifluoro...

3-(3-三氟甲基苯基)丙酸甲酯置于水,Sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,以3.9 G的收率获得产物3-(3-三氟甲基苯基)丙酸
参考文献:盐酸西那卡塞及其中间体的制备方法
标题:盐酸西那卡塞及其中间体的制备方法
摘要:本发明公开了一种盐酸西那卡塞及其中间体的制备方法.本发明提供了一种盐酸西那卡塞中间体l‑酒石酸西那卡塞iii的制备方法,其包括步骤(1):在有机溶剂中,手性催化剂和手性配体存在下,将西那卡塞中间体ii进行不对称氢化还原反应得到西那卡塞iv,手性催化剂为双(1,5‑环辛二烯)‑三氟甲磺酸铑,手性配体为(S)‑3,3'‑双(2,4,6‑三异丙基苯基)‑1,1'‑二‑2‑萘酚环磷酸酯;步骤(2):有机溶剂中,将西那卡塞iv与l‑酒石酸进行中和反应,得到l‑酒石酸西那卡塞iii.本发明的制备方法,路线步骤短,操作简单安全,总收率高,制得的产品纯度高,达到原料药要求,生产成本低,适合于工业化生产.

专利信息

专利号:EP-1990333-A1
优先权日:2007-05-11
标题 :Process for the preparation of cinacalcet hydrochloride
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of cinacalcet hydrochloride which is industrially feasible and commercially viable. The synthesis of cinacalcet hydrochloride is carried out by the condensation of 3-trifluromethylphenyl propionic acid with R-(+)-1-(lnaphthyl)ethylamine.

专利号:US-7361789-B1
优先权日:2004-07-28
标 题 :Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
发明人：YAN QI; ORIHUELA CARLOS; SHEN BO; CHEN YING; WANG XIN; NG JOHN; JI RUIZHI; ZHOU PENGZU
权利人:AMGEN INC
摘要:The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.

专利号:CN-109456201-A
优先权日:2018-11-12
标 题 :A kind of method for asymmetric synthesis of (R)-cinacalcet

专利号:CN-109456201-B
优先权日:2018-11-12
标 题 :A kind of method for asymmetric synthesis of (R)-cinacalcet

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:CN-111018734-B
优先权日:2019-12-13
标 题 :Synthesis method of cinacalcet hydrochloride intermediate