CAS: 5618-03-1; 3-Cyclopropylpropanoic Acid

该化合物是一种有机化合物,其特点是与丙酸脊柱相连的环丙基化合物;其一端为三碳链,其三碳酸功能组(-COOH),其一面为碳本酸组,第三碳位置为环丙酸环;这一结构具有独特的特性,包括由于环丙醇环的菌株而有可能增加反应性;该化合物一般无色,不光彩,不粉黄液体或固体,视温度和纯度而定;有机溶剂中可溶解,并显示由于极致癌酸组而在水中出现中等溶性. 3-丙丙丙基丙基异丙酸可参与各种化学反应,包括酯化和恐吓,使其对有机合成和药用化学感兴趣;其独特结构还可能影响其生物活动,有可能导致药物或农业化学的应用;在处理和储存方面,应参考安全数据,如任何化学物质一样.

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62021-36-7 5266-72-8 5618-01-9

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上下游产品

diazomethane cyclopropylacetyl chloride (2-bromoethyl)cyclopropane carbon dioxide cyclopropylpropionyl chloride 3-cyclopropyl-1-propanol 3-cyclopropyl-1-(4-(3,4-dimethoxyphenyl)piperidin-1-yl)-propan-1-one N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-cyclopropylpropanamide

合成工艺路线路线简述

    📜环丙乙酸置于lithium Aluminium Tetrahydride,三溴化磷体系中,用 乙醚 作为反应溶剂,化学反应生成 3-环丙基丙酸
    参考文献:Maercker,A.; Theysohn,W.,Justus Liebigs Annalen Der Chemie,1972,Vol. 759,P. 132-157
    标题:Maercker,A.; Theysohn,W.,Justus Liebigs Annalen Der Chemie,1972,Vol. 759,P. 132-157

    海关参考信息

    专利信息


    专利号:US-2025091989-A1
    优先权日:2023-09-19
    标 题 :Small molecule protein synthesis modulators
    发明人:GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
    权利人:INTERDICT BIO INC
    摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

    专利号:US-4661626-A
    优先权日:1985-03-11
    标题 :Process for the production of 2-isocyanato-2,3-dehydrocarboxylic acid esters
    发明人:EFFENBERGER FRANZ; KUEHLWEIN JUERGEN; DRAUZ KARLHEINZ
    权利人:DEGUSSA
    摘要:There are produced 2-isocyanato-2,3-dehydrocarboxylic acid esters of the general formula: (I) in which R1 is a straight chain or branched C1-C4-alkyl group, a phenyl group or a benzyl group, R2 is hydrogen or a methyl group and R3 is hydrogen, a straight chain or branched C1-C16-alkyl group, a C3-C8-cycloalkyl group, a C1-C6-alkylmercapto group or a phenyl group by reacting a 2-azido-carboxylic acid ester of the general formula: (II) in an inert solvent at a temperature between 0 DEG and 150 DEG C. with phosgene or diphosgene in the presence of a perrhenate. The compounds of general formula (I) can be converted into the corresponding Z- or BOC-protected 2,3-dehydro-2-amino-carboxylic acid ester with benzyl alcohol or with tert. butyl alcohol, which esters in turn are valuable building blocks for the synthesis of dehydropeptides.

    专利号:US-2005009151-A1
    优先权日:2003-07-10
    标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
    发明人:CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
    权利人:PHARMACIA CORP
    摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

    专利号:US-4093622-A
    优先权日:1975-05-19
    标题 :Pyridine esters of cyclopropane-carboxylic acid
    发明人:HENRICK CLIVE A; STAAL GERARDUS B
    权利人:ZOECON CORP
    摘要:Heterocyclic organic esters and thioesters characterized by the presence of one or two cyclopropane moieties, synthesis thereof, and compositions thereof for the control of mites and ticks.

    专利号:US-3876682-A
    优先权日:1973-06-04
    标题 :Substituted benzoates of cyclpropane carboxylic acids
    发明人:HENRICK CLIVE A; STALL GERARDUS B
    权利人:HENRICK CLIVE A; STALL GERARDUS B
    摘要:Organic esters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

    专利号:RU-2117670-C1
    优先权日:1988-10-31
    标 题 :Derivatives of triazolo[1,4]diazepine and methods of their synthesis

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Durandetti, M.; Franck, X., Science of Synthesis: Knowledge Updates, (2024) 3, 344.
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