CAS: 5405-40-3; (S)-3-Hydroxy-4,4-Dimethyldihydrofuran-2(3H)-One

相似化合物

599-04-2 79-50-5 13031-04-4

上下游产品

Dl-泛酰内酯 Pantolactone 79-50-5
D-(-)-泛酰内酯 (R)-Pantolacton 599-04-2
(Rs)-2-Acetoxy-3,3-Dimethyl-γ-Butyrolactone 28227-35-2
(S)-2-Acetoxy-3,3-Dimethyl-γ-Butyrolactone 28387-34-0
γ-二甲基丁内酯 Pantoyllacton 13861-97-7
(R)-Ethyl 2-Hydroxy-3,3-Dimethyl-4-Oxobutanoate 1196498-52-8
(2S)-2,4-二羟基-3,3-二甲基丁酸 L-Pantoic Acid 1112-32-9
(S)-2-Hydroxy-3,3-Dimethyl-Bernsteinsaeuredimethylester 68984-72-5
(S)-3-(Benzyloxy)-4,4-Dimethyldihydrofuran-2(3H)-One

📜2,2-二甲基-3-羟基丙醛置于水,Calcium Chloride,奎宁体系中,化学反应生成 (S)-(+)-泛解酸内酯
参考文献:Reichstein; Gruessner,Helvetica Chimica Acta,1940,Vol. 23,P. 653
标题:Reichstein; Gruessner,Helvetica Chimica Acta,1940,Vol. 23,P. 653

专利信息

专利号:WO-2023078722-A1
优先权日:2021-11-02
标题 :Synthesis of pantothenic acid butyrate
发明人：BONRATH WERNER; EGGERTSWYLER CHRISTOPHE; PACE FRANCESCO
权利人:DSM IP ASSETS BV
摘要:The present invention relates to new specific butyrate compounds to a new and improved synthesis of specific butyrates as well their use. Butyrate compounds are very useful compounds, either as such or as intermediates in organic synthesis.

专利号:WO-2019228873-A1
优先权日:2018-05-31
标 题:Synthesis of a racemic mixture of pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The invention relates to an improved synthesis of a racemic mixture of pantolactone (I).

专利号:WO-2019228874-A1
优先权日:2018-05-31
标 题 :Stereoselective synthesis of enantiomerically-enriched pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone.

专利号:EP-3819295-A1
优先权日:2019-11-07
标 题 :Stereoselective synthesis of enantiomerically-enriched pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN ALAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone of formula (I) or (I').

专利号:EP-0528256-B1
优先权日:1991-08-12
标 题:D-2,4-dihydroxy-3,3-dimethylbutyronitrile, its production and use and process for production of D-pantolactone, D-2,4-dihydroxy-3,3-dimethylbutyramide and D-pantothenic acid
发明人：BEISSWENGER THOMAS DR; HUTHMACHER KLAUS DR; KLENK HERBERT DR
权利人:DEGUSSA
摘要:2.1. D-(-)-Pantolactone is an important intermediate in the synthesis of D-(+)-pantothenic acid or D-panthenol and can be obtained from the racemic compound by elaborate racemate resolution methods in the form of pantoic acid salts with chiral auxiliary bases and subsequent resolution of the pairs of salts with subsequent cyclisation of the pantoic acid. Since this synthesis is very elaborate, the object of the present invention is to provide a more suitable intermediate for pantolactone synthesis, which is to be obtainable straightforwardly and at low cost. 2.2. Such an intermediate is D-2,4-dihydroxy-3,3-dimethylbutyronitrile in an optical purity (D:L) of at least 80:20. D-(-)-pantolactone can be prepared in high yields by hydrolysis of the nitrile with concentrated acids. The nitrile is obtainable by reaction of hydroxypivalaldehyde with hydrogen cyanide in the presence of relatively large amounts of a D-oxynitrilase. 2.3. Preparation of D-(-)-pantolactone and D-(+)-pantothenic acid.

专利号:EP-3748009-A1
优先权日:2019-06-07
标 题 :Synthesis of (r)-pantolactone acetate
发明人：BEKERLE-BOGNER MYRIA; MEDLOCK JONATHAN ALAN; STEINKELLNER GEORG; STROHMEIER GERNOT; STEINER KERSTIN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a 2-step process comprising step (1) kinetic resolution of R/S-pantolactone using an enantioselective acetylating enzyme and step (2) racemization of (S)-pantolactone in the presence of at least one specific chemical catalyst leading to highly enriched (R)-pantolactone acetate. Both step (1) and (2) might be carried-out in a one-pot reaction/system.