CAS: 53657-15-1; (R)-β-(2-Propyl)-γ-Butyrolactone

上下游产品

4-Hydroxy-3-Isopropylbutyro-1,4-Lactone 89359-09-1
(S)-4-叔丁氧-2-异丙基-4-氧丁酸 (S)-4-(Tert-Butoxy)-2-Isopropyl-4-Oxobutanoic Acid 134807-43-5

📜(4S)-3-<1-Oxo-3-(1,3-Dithian-2-Ylidene)-2-(2-Propyl)Propyl>-4-(1-Methylethyl)-2-Oxazolidinone置于lithium Aluminium Tetrahydride,对甲苯磺酸体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 1.5H,反应生成 布立西坦杂质19
参考文献:Enantioselective Preparation Of .Beta.-Alkyl-.Gamma.-Butyrolactones From Functionalized Ketene Dithioacetals
标题:Enantioselective Preparation Of .Beta.-Alkyl-.Gamma.-Butyrolactones From Functionalized Ketene Dithioacetals
摘要:An Efficient And General Enantioselective Synthesis Of Beta-Alkyl-Gamma-Butyrolactones Has Been Developed. The Key Step Of This Procedure Is An Oxazolidinone-Directed Alkylation Of A Lithiated Ketene Dithioacetal That Proceeds With Excellent Regiochemical Control And High Diastereofacial Selectivity. Reductive Removal Of The Chiral Auxiliary Followed By Acid-Induced Cyclization Of The Resultant Hydroxy Ketene Dithioacetal Gives The Enantiomerically Pure Beta-Alkyl-Gamma-Butyrolactone.
DOI:10.1021/jo00062A013

专利信息

专利号:CN-111116598-A
优先权日:2018-11-01
标 题 :Asymmetric synthesis of a class of antipsychotic drugs

专利号:CN-110922412-A
优先权日:2018-09-20
标题:Asymmetric synthesis of pharmaceutical compounds with antipsychotic effects