CAS: 534-03-2; 2-Aminopropane-1,3-Diol

上下游产品

CAS号96-26-4 1,3-二羟基丙酮 | CAS号91843-21-9 1,3-Dioxan-5-am... | CAS号2788-84-3 L-丝氨酸甲酯 | CAS号6829-41-0 异亚硝基丙二酸二乙酯 | CAS号62147-49-3 1,3-二羟基丙酮二聚体 | CAS号5680-80-8 L-丝氨酸甲酯盐酸盐 | CAS号84820-75-7 4-Hydroxymethyl... | CAS号24070-20-0 2-氨基-1,3-丙二醇草酸酯 | CAS号1794-90-7 2-Nitro-1,3-pro... | CAS号64-17-5 乙醇 | CAS号188538-25-2 2,2,3,3,9,9,10,... | CAS号24070-19-7 2-(2-benzhydryl... | CAS号2655-79-0 N-(1,3-dihydrox... | CAS号141-46-8 羟乙醛 | CAS号60166-93-0 碘帕醇 | CAS号71811-26-2 n-cbz-2-氨基-1,3-丙二醇 | CAS号125414-41-7 N-B°C-丝氨醇 | CAS号115250-39-0 四苄基伏格列波糖 | CAS号126127-31-9 N-palmitoylserinol | CAS号651354-84-6 3-[2-amino-3-(2...

L-丝氨酸置于硫酸,氢气体系中,用 水 作为反应溶剂,79.84 °C,8.0 Mpa 条件下,以92.8%的收率获得产物丝氨醇
参考文献:将氨基酸催化氢化为氨基醇,并完全保留构型.
标题:将氨基酸催化氢化为氨基醇,并完全保留构型.
摘要:Rh-Moox / Sio2是有效的非均相催化剂,用于在水溶剂中将氨基酸选择性加氢为氨基醇.moox修饰rh大大提高了活性,并提高了选择性和ee.以高收率(90-94%)获得了各种氨基醇,并完全保留了构型.
DOI:10.1039/c4Cc02675F

专利信息

专利号:US-7329515-B2
优先权日:2003-04-21
标题 :Solid support for the synthesis of 3′-amino oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.

专利号:US-5736626-A
优先权日:1996-01-29
标题:Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
发明人：MULLAH KHAIRUZZAMAN BASHAR; ANDRUS WILLIAM A
权利人:PERKIN ELMER CORP
摘要:The compounds of the invention are exemplified by the class of diglycolate synthesis supports particularly useful as support reagents for the direct synthesis of 3'-labeled polynucleotides. Generally, the compounds of the invention have the structure ##STR1## where T is an acid-cleavable hydroxyl protecting group, e.g., 4,4'-dimethoxytrityl; L 1 is a linker for connecting a 3'-terminal nitrogen to carbon; L 2 and L 3 are linkers for connecting oxygen and carbon; W is a solid support, e.g., CPG or polystyrene; L 4 is a linker for connecting the solid support to nitrogen; R 1 and R 2 are nitrogen substituents, e.g., hydrogen, lower alkyl, nitrogen protecting group, or label; and R 3 through R 7 are carbon substituents, e.g., hydrogen or lower alkyl. In a first particularly preferred embodiment, the synthesis supports of the invention are exemplified by compounds having the structure ##STR2## where DMT is 4,4'-dimethoxytrityl and W is polystyrene. In a second particularly preferred embodiment, the synthesis supports of the invention are exemplified by compounds having the structure ##STR3## where DMT and W are defined above.

专利号:US-2022401910-A1
优先权日:2019-12-02
标 题 :Apparatus for the synthesis of oligonucleotides and process for the preparation thereof
发明人：AEMISSEGGER ANDREAS; DUGOVIC BRANISLAV; JAUKER MARIO; STAUSS MARTIN
权利人:BACHEM AG
摘要:The present invention provides apparatuses and methods for the synthesis of oligonucleotides and related compounds. In particular, the present invention allows to effectively prepare reagents to be fed into an apparatus for the synthesis of such oligomers.

专利号:US-7705136-B2
优先权日:2005-02-25
标 题 :Synthesis of 3′-, or 5′-, or internal methacrylamido-modified oligonucleotides
发明人：GOLOVA JULIA B; CHERNOV BORIS K
权利人:UCHICAGO ARGONNE LLC
摘要:New modifiers were synthesized for incorporation of a methacrylic function in 3′-, 5′- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5′-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.

专利号:US-2024368099-A1
优先权日:2022-01-18
标 题:Methods for the synthesis of di(hydroxymethyl)tetrahydrofuran and its application in polyesters and polyurethanes
发明人：SPIEGELBERG BRIAN; BRANDT ADRIAN; BECK HORST; KUX ALEXANDER; TIN SERGEY; DE VRIES JOHANNES GERARDUS
权利人:HENKEL AG & CO KGAA
摘要:The present invention relates to the synthesis of di(hydroxymethyl)tetrahydrofuran (DHMTHF) and the preparation of trans-enriched mixtures of DHMTHF. The invention further refers to polyester polyols which are obtained by reaction of cis/trans DHMTHF mixtures with a dicarboxylic acid. The invention further relates to polyurethanes and compositions containing a polyester polyol comprising DHMTHF, in particular to such polyurethane-containing (adhesive) compositions.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.