CAS: 45644-21-1; 2-Amino-6-Chloropyridine

相似化合物

159603-71-1 94166-64-0 116632-24-7

上下游产品

2,6-dichloropyridine 6-chloro-pyridine-2-carbonyl azide 3-hydroxyglutaronitrile N-(6-chloropyridin-2-yl)acetamide 2-amino-6-methoxypyridine 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 2-amino-6-N,N-dimethylamino pyridine pyridine hydr°Chloride5-chloro-2-methylimidazo1,2-apyridine hydr°Chloride

2,6-二氯吡啶置于ammonium Hydroxide体系中,125.0 °C,200.0 Kpa 条件下,反应 5.0H,以79%的收率获得产物2-氨基-6-氯吡啶
参考文献:大规模合成具有环12π-电子环系统的新环嗪,5-Thia-1,8 B-二氮杂ena烯-3-羧酸衍生物
标题:大规模合成具有环12π-电子环系统的新环嗪,5-Thia-1,8 B-二氮杂ena烯-3-羧酸衍生物
摘要:5-Thia-1,8B-二氮杂ena烯(2及其酯8)是新的环嗪,其中顺磁环存在于外围的12π电子环系统中.已经开发了三种方便的制备方法8.其中一项涉及新化合物5-氟咪唑并[1,2-A]吡啶(6B)的巯基乙醇化反应,然后进行duff反应,无需色谱纯化即可得到64%收率的8.
DOI:10.1016/s0040-4020(01)01171-1

专利信息

专利号:WO-2009018504-A1
优先权日:2007-08-01
标题 :Process for the synthesis of diaminopyridine and related compounds
发明人：RITTER JOACHIM C
权利人:DU PONT; RITTER JOACHIM C
摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:WO-2009018502-A2
优先权日:2007-08-01
标 题:Process for the synthesis of diaminopyridine and related compounds

专利号:CN-101765588-A
优先权日:2007-08-01
标 题 :Process for the synthesis of diaminopyridine and related compounds