CAS: 33025-41-1; 2,3,4,4'-Tetrachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,这是合成有机化学品,以其环境持久性和潜在毒性而著称,这种化合物具有两个联苯环,以单一的联结连接,四个氯原子在联苯结构上以特定位置替换,其物理特性包括水中的熔点相对较高,溶解性较低,使其在有机溶剂中更易溶解. 2,3,4,4,4欧元四氯联苯的特点是其稳定性和耐降解性,这助长了其在环境和活生生物体中的积累.由于它具有生物蓄积性及其相关的健康风险,包括内分泌干扰和致癌效应,因此被归类为一种危险物质.已实施了管制措施,以限制其使用和释放到环境中,这反映出对多氯联苯的生态和人类健康影响日益关切.

英文名称2,3,4,4'-Tetrachlorobiphenyl
中文名称2,3,4,4'-四氯联苯
IUPAC名称1,2,3-trichloro-4-(4-chlorophenyl)benzene
其它别名Biphenyl,2,3,4,4'-tetrachloro- (8CI); 2,3,4,4'-Tetrachloro-1,1'-biphenyl; 2,3,4,4'-Tetrachlorobiphenyl; 4,2',3',4'-Tetrachlorobiphenyl; PCB 60
CAS编号33025-41-1
MFCD编号:MFCD00152843
FDA UNII编号:GOZ3B4WZGW
分子式:C12H6Cl4分子量:291.99
产品CID: 1323440
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: XLDBTRJKXLKYTC-UHFFFAOYSA-N
1S/C12H6Cl4/c13-8-3-1-7(2-4-8)9-5-6-10(14)12(16)11(9)15/h1-6H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4-trichloroaniline chlorobenzene 4-chloro-aniline 1,2,4-Trichlorobenzene 1,2,3,7-tetrachlorodibenzofuran

合成工艺路线路线简述

📜2,3,4-三氯苯胺,氯苯置于sodium Acetate,亚硝酸体系中,化学反应生成2,3,4,4'-四氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
Doi:10.1016/0045-6535(95)00140-4