CAS: 26078-25-1; 7-(Ethylamino)-4,6-Dimethyl-2H-Chromen-2-One

📜3-(乙基氨基)-4-甲酚,乙酰乙酸乙酯 以38%的收率获得
参考文献:Grandberg,I. I.;Denisov,L. K.;Melnikova,L. M.;Popova,O. A.;Tokmakov,+,Izv. Timiryazev. S.-X. Akad.,1984,N 4,149-152
标题:Grandberg,I. I.;Denisov,L. K.;Melnikova,L. M.;Popova,O. A.;Tokmakov,+,Izv. Timiryazev. S.-X. Akad.,1984,N 4,149-152

专利信息

专利号:US-6420571-B2
优先权日:1999-04-26
标 题:Methods for preparing antiviral calanolide compounds
发明人：XU ZE-QI; YUAN HONGWEI; CRABB JENNIFER; SAMY RAGHU; LI AILING; CAO HUA
权利人:SARAWAK MEDICHEM PHARMACEUTICALS INC
摘要:The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy -10-propyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10 -propyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy -6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (-)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.

专利号:US-11584752-B2
优先权日:2020-09-08
标题 :Method for controlled release using mechanical force
发明人：ROBB MAXWELL J; HU XIAORAN; ZENG TIAN
权利人:CALIFORNIA INST OF TECHN
摘要:A general and modular mechanophore platform that efficiently releases a cargo molecule via a mechanically triggered cascade reaction is described, along with methods of synthesis and use thereof. The mechanophore platform comprises a stable Diels-Alder adduct mechanophore comprising a 2-furylcarbinol derivative as its diene component, wherein the 2-furylcarbinol derivative is, in turn, pre-loaded with a covalently attached cargo molecule, and wherein the Diels-Alder adduct mechanophore is embedded into a polymer chain or polymer network, such that the mechanophore platform undergoes the retro [4+2] cycloaddition reaction under mechanical force to reveal the unstable 2-furylcarbinol derivative, which, in turn, easily decomposes under mild conditions to release its molecule cargo.

专利号:US-6475363-B1
优先权日:1994-08-01
标 题:Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
发明人：RAMSEY J MICHAEL
权利人:UT BATTELLE LLC
摘要:A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

专利号:DK-2619281-T3
优先权日:2010-09-21
标 题 :Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from inoculation of these coumarins onto sugars, processes for making these substrates, and their applications