CAS: 25440-14-6; 5,10,15,20-Tetrakis(Pentafluorophenyl)-21H,23H-Porphine

该化合物是合成的败血剂化合物,其特点是其结构复杂,包括一种用四种五氟苯基组群替代的灭火器核心,这种替代大大提高了其电子脱色性能,使其在光动疗法,传感器和各种化学反应中的催化剂方面成为强大的应用对象.氟化原子的存在有助于其在有机溶剂中的稳定性和溶解性,同时还具有独特的光学特性,例如在电磁频谱的可见区域中产生强烈吸收.该化合物通常表现出一种深色,通常以生动紫色或红色溶液出现.其高热和化学稳定性使其能够承受严酷的条件,使之适合各种工业和研究应用.此外,多种氟化群体的存在可以影响其与生物系统的互动,有可能提高其在定向疗法中的功效.总体而言,5,10,15,20-ttrakis(五溴二苯醚)的ptrafrin是一种多用途化合物,对材料科学和药用化学都有重大影响.

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pyrrole perfluorobenzaldehyde 2,6-Dicyanobenzaldehyde 4-formylphenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

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    专利信息


    专利号:US-7417142-B2
    优先权日:2002-03-28
    标 题:Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same
    发明人：ZHANG X PETER; CHEN YING; GAO GUANG-YAO
    权利人:UNIV TENNESSEE RES FOUNDATION
    摘要:Novel methods of synthesizing heteroatom-containing chiral porphyrins and chiral metalloporphyrins and the novel chiral porphyrins and chiral metalloporphyrins themselves are disclosed. Metal complexes of the chiral porphyrins are prepared in high yields and shown to be active catalysts for highly enantioselective and diastereoselective cyclopropanation, aziridination, and epoxidation of alkenes under a practical one-pot protocol.

    专利号:US-9868767-B2
    优先权日:2013-05-23
    标 题:Chemical synthesis and screening of bicyclic peptide libraries
    发明人：PEI DEHUA; UPADHYAYA PUNIT; LIAN WENLONG; TRINH THI
    权利人:OHIO STATE INNOVATION FOUNDATION
    摘要:Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:US-2005124596-A1
    优先权日:2002-03-28
    标 题 :Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same

    专利号:US-10654812-B2
    优先权日:2014-03-07
    标 题:Propellane derivates and synthesis
    发明人：BUNKER KEVIN DUANE
    权利人:KALYRA PHARMACEUTICALS INC; RECURIUM IP HOLDINGS LLC
    摘要:Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).

    专利号:US-2015328617-A1
    优先权日:2011-08-29
    标题:Method and device for the synthesis of artemisinin

    专利号:US-2014364630-A1
    优先权日:2011-08-29
    标 题:Method and device for the synthesis of artemisinin

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    主要参考文献

    1.) Samaroo, D., Vinodu, M., Chen, X., Drain, C. M., meso-Tetra(pentafluorophenyl)porphyrin as an Efficient Platform for Combinatorial Synthesis and the Selection of New Photodynamic Therapeutics using a Cancer Cell Line, Comb. Chem.2007, 9, 06, 998–1011. 2.) Samaroo, D., Soll, E. C., Todar, L.J., Drain, C. M., Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin, Org. Lett. 2006, 8, 22, 4985–4988. 3.) Wu, et al. Hydrogen gas generation using a metal-free fluorinated porphyrin Chem. Sci., 2018, 9, 4689-4695 DOI: 10.1039/C8SC00093J 4.) de Souza, et al. Porphyrins as Photoredox Catalysts in Csp2–H Arylations: Batch and Continuous Flow Approaches. J. Org. Chem. 2018, 83, 24, 15077–15086. 5.) Hemant Kumar, et al. Ultrafast Relaxation Dynamics of 5,10,15,20-meso-Tetrakis Pentafluorophenyl Porphyrin Studied by Fluorescence Up-Conversion and Transient Absorption Spectroscopy. J. Phys. Chem. A 2015, 119, 8, 1267–1278. 6.) Foletto, et al. A New Protocol for the Synthesis of New Thioaryl-Porphyrins Derived from 5,10,15,20-Tetrakis(pentafluorophenyl)porphyrin: Photophysical Evaluation and DNA-Binding Interactive Studies. Molecules 2018, 23(10), 2588; doi.org/10.3390/molecules23102588 7.) Wyrebek, et al. An Approach to Pyrazoline-Fused Chlorins by Dipolar [3 + 2]-Cycloaddition of Iminonitriles to meso-Tetrakis(pentafluorophenyl)porphyrin: Synthesis of New PDT Photosensitizers. Bulletin of the Chemical Society of Japan 2012, Vol.85, No.10 1167-1174https://doi.org/10.1246/bcsj.20110408

    合成参考文献


    摘要:Jux, N.; Montforts, F.-P.; Haake, E., Science of Synthesis Knowledge Updates, (2022) 1, 95.
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