CAS: 25391-57-5; 5-Iodo-3-Nitropyridin-2-Amine

该化合物是一种卤代硝基氨基丙烯衍生物,在合成有机化学方面非常有用,其结构以5位置的碘替代物和3位置的硝基罗组为特征,使其成为核生殖替代和交叉相交反应的多功能中间体.电离式硝基罗组会增强再活性,而碘原子则通过金属催化合体为进一步功能化提供处理器.该复合体在建造复杂的多环形纸浆的制药和农用化学研究中特别有价值,其稳定性在标准条件下和定义明确的再活动简介下确保多步合成物的一贯性能.

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相似化合物

790692-90-9 25391-56-4 351447-13-7

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上下游产品

CAS号4214-75-9 2-氨基-3-硝基吡啶 | CAS号426463-01-6 2-氨基-5-碘-3-吡啶胺 | CAS号426463-09-4 3-氨基-2-氯-5-碘吡啶 | CAS号426463-05-0 2-氯-5-碘-3-硝基吡啶 | CAS号426463-16-3 2-氟-5-碘-3-硝基吡啶

合成工艺路线路线简述

    📜2-氨基-3-硝基吡啶置于硫酸,溶剂黄146,高碘酸,碘体系中,化学反应 1.25H,以99%的收率获得2-氨基-5-碘-3-硝基吡啶
    参考文献:2-Exo-2-(2',3'-二取代的5'-吡啶基)-7-氮杂双环[2.2.1]庚烷的合成,烟碱乙酰胆碱受体结合和抗伤害感受特性:Epibatidine类似物.
    标题:2-Exo-2-(2',3'-二取代的5'-吡啶基)-7-氮杂双环[2.2.1]庚烷的合成,烟碱乙酰胆碱受体结合和抗伤害感受特性:Epibatidine类似物.
    摘要:合成了许多2',3'-二取代的epibatidine类似物,并在体外评估了其对烟碱乙酰胆碱受体(nachrs)的效力,并在体内对急性疼痛的甩尾和热板模型中的抗伤害感受活性及其功能进行了评估.影响核心体温.在2'和3'位置均具有吸电子基团(f,Cl,Br和i)的化合物在nachr上的亲和力与epibatidine相似.但是,体内功效与亲和力无关.2-Exo-(3'-Amino-2'-Chloro-5'-吡啶基)-7-氮杂双环[2.2.1]庚烷(2I),一种在3'-位具有电子释放氨基的表巴替丁类似物,产生了最高的亲和力.化合物2I也是最具选择性的依巴替丁类似物,在字母nachrs处的k(i)为0.001 Nm,它是epibatidine的26倍,并且alphaa / Alpha(7)k(i)的比率为14,000,是epibatidine的两倍.体内测试表明,该化合物有效抑制尼古丁引起的抗伤害感受,其ad(50)值低于1
    Doi:10.1021/jm0202268

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    专利信息


    专利号:US-3963734-A
    优先权日:1971-09-17
    标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines
    发明人：DOHERTY GEORGE O P; FUHR KENNETH H
    权利人:LILLY CO ELI
    摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

    专利号:US-9708336-B2
    优先权日:2014-01-22
    标题 :Metallo-beta-lactamase inhibitors
    发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

    专利号:US-4087432-A
    优先权日:1974-05-23
    标 题 :1H-imidazo(4,5-b)pyridine compounds
    发明人：O DOHERTY GEORGE O P; FUHR KENNETH H
    权利人:LILLY CO ELI
    摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

    专利号:US-3968116-A
    优先权日:1971-09-17
    标 题 :1H-imidazo(4,5-b)pyridine compounds
    发明人：DOHERTY GEORGE O P; FUHR KENNETH H
    权利人:LILLY CO ELI
    摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

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    合成参考文献

    参考DOI号:10.1021/jm0202268
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