CAS: 22428-87-1; 1,4-Dioxaspiro[4.5]Decan-8-Ol

相似化合物

4746-97-8 177-10-6 92829-83-9

上下游产品

1,4-Dioxaspiro[4.5]Decan-8-Yl Acetate 54621-09-9
1,4-环己二酮单乙二醇缩酮 Cyclohexanedione Monoethylene Ketal 4746-97-8
2-Hydroxycyclohexanone Ethylene Ketal 78881-14-8
1,2-环己二酮环乙缩醛 1,4-Dioxaspiro[4.5]Decan-6-One 4746-96-7

1,4-Dioxaspiro[4.5]Decan-8-Yl Acetate置于diethylzinc,Lithium Chloride,Sodium Hydroxide体系中,用 四氢呋喃,正己烷,水 用作溶剂,化学反应 14.0H,以98%的收率获得4-羟基环己酮乙二醇缩醛
参考文献:轻度条件下高效高效的锌选择性化学催化的锌氢化硅烷化
标题:轻度条件下高效高效的锌选择性化学催化的锌氢化硅烷化
摘要:使用二乙基锌作为催化剂,已开发出一种温和而高效的催化氢化硅烷化方案,可用于室温酯的还原.该方法操作简单,显示出较高的官能团耐受性,并且可以轻松获得各种不同醇的高收率.
Doi:10.1002/chem.201406176

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-9751874-B2
优先权日:2014-12-17
标题:Hydroxy containing FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-2006292073-A1
优先权日:2005-06-23
标 题 :Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging

专利号:WO-2007001958-A2
优先权日:2005-06-23
标 题:Stereoselective synthesis of amino acid analogs for tumor imaging

专利号:WO-9725992-A1
优先权日:1996-01-16
标 题 :Tocolytic oxytocin receptor antagonists
发明人：SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D
权利人:MERCK & CO INC; SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D
摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.