CAS: 214894-89-0; 5-(Bromomethyl)-2,3-Dihydro-1,4-Benzodioxine
该化合物是1,4-benzodioxane的溴化衍生物,在5个位置上有一个反应型的溴二苯氧组,该化合物是有机合成的多用途中间体,特别是在建造药用活分子和功能化异环的过程中.该化合物通过核生殖替代或交叉反应促进进一步衍生,从而能够引入多种功能组.其硬性双二恶英剑片有助于结构稳定,使其在药用化学和材料科学中具有价值.该化合物由于对湿度和光的敏感度,通常在不热条件下处理,其合成效用和定义明确的再活动特征使它成为先进化学应用的有用建筑块.
- 英文名称5-(Bromomethyl)-2,3-Dihydro-1,4-Benzodioxine
- 中文名称5-溴甲基-2,3-二氢-1,4-苯并二噁烯
- IUPAC名称5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine
- 其它别名5-(Bromomethyl)-2,3-Dihydro-1,4-Benzodioxin; 5-(Bromomethyl)-2,3-Dihydro-1,4-Benzodioxine; 5-(Bromomethyl)-2,3-Dihydro-1,4-Benzodioxine,; 5-(Bromomethyl)-2,3-Dihydrobenzo[b][1,4]Dioxine; 1,4-Benzodioxin, 5-(Bromomethyl)-2,3-Dihydro-
- CAS编号214894-89-0
- MFCD编号:MFCD05664400
- 分子式:C9H9BrO2分子量:229.07
- 产品CID: 1116808
- 产品分类化学试剂 → 有机试剂 → 双环化合物
物理性质
MSDS等安全信息
上下游产品
CAS号33632-34-7 2,3-dihydro-5-m... | CAS号488-17-5 3-甲基邻苯二酚 | CAS号261633-71-0 2,3-二羟基-1,4-苯并二...合成工艺路线路线简述
📜5-Methyl-2,3-Dihydro-1,4-Benzodioxin置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 四氯化碳 用作溶剂,化学反应生成5-溴甲基-2,3-二氢-1,4-苯并二噁烯
参考文献:Substituted Oxygenated Heterocycles And Thio-Analogues: Synthesis And Biological Evaluation As Melatonin Ligands
标题:Substituted Oxygenated Heterocycles And Thio-Analogues: Synthesis And Biological Evaluation As Melatonin Ligands
摘要:A New Series Of Substituted Oxygenated Heterocycles And Thio-Analogues Were Synthesized And Evaluated As Melatonin Receptor Ligands. The Replacement Of The Indolic Moiety Of Melatonin By Heterocyclic Skeleton Such As 1,4-Benzodioxin,2,3-Dihydro-1,4-Benzodioxin,Chroman,2,3-Dihydro-1,4-Benzoxathiin,Thiochroman,Carrying The Amidic Chain On The Aromatic Ring,Leads To Compounds Showing A Weak Affinity For Melatonin Receptors,Except For The Compounds 1Cb And 1Hb. (C) 2000 Elsevier Science Ltd,All Rights Reserved.
Doi:10.1016/s0968-0896(99)00265-5
海关参考信息
- 2902300000-甲苯
2905310000-1,2-乙二醇
2907210001-间苯二酚
2903399020-溴甲烷 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.
