CAS: 210537-32-9; 2,6-Bis[1-(2-Methylphenylimino)Ethyl]Pyridine

上下游产品

CAS号1129-30-2 2,6-二乙酰基吡啶 | CAS号95-53-4 邻甲苯胺

📜2,6-二乙酰基吡啶,邻甲苯胺置于甲酸体系中,用 二氯甲烷 用作溶剂,化学反应 96.0H,以42%的收率获得2,6-双[1-(2-甲基苯咪唑)乙基]吡啶
参考文献:在甲基-丁基咪唑鎓有机氯铝酸盐离子液体中使用双(亚氨基)吡啶钴配合物进行双相乙烯低聚
标题:在甲基-丁基咪唑鎓有机氯铝酸盐离子液体中使用双(亚氨基)吡啶钴配合物进行双相乙烯低聚
摘要:已经合成了几种双(亚氨基)吡啶钴(II)配合物,并将其用于由甲基铝氧烷(mao)活化的1-甲基-3-丁基咪唑鎓四氯铝酸盐(bmi.alcl 4)离子液体中的乙烯低聚.在芳族基团的邻位和对位具有卤素,甲基或三氟甲基单元的配体取代模式对活性和选择性具有显着影响.在这项工作中评估的钴催化剂表现出4000-15,300 H-1的活性,并且对乙烯二聚为丁烯的选择性高于90%.这些催化剂还显示出对1-丁烯形成的高选择性,高达87%.
Doi:10.1016/j.Molcata.2011.03.015

专利信息

专利号:WO-2023151188-A1
优先权日:2022-02-08
标题 :Green synthesis method of antiviral drug intermediate
发明人：XIA BIN; WANG JIAMING; ZHANG XIANSHU; CAI LINGLI; WANG ZIKUN; CAO MING; YANG SHAOBO; GAO QIANG; ZHENG BAOFU
权利人:SHANGHAI HAOYUAN CHEMEXPRESS CO LTD
摘要:The present application provides a green synthesis method of an antiviral drug intermediate. The method comprises: in the presence of a catalyst, adding zinc powder into a compound as represented by a formula II and performing a cyclization reaction with dihaloalkane to generate a compound as represented by a formula I, zinc halide being not required to be added to the cyclization reaction, wherein R1 is selected from H or an amino-protecting group, and R2 is selected from substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C6-C14 aryl or substituted or unsubstituted C7-C14 aralkyl; R3 and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-C10 alkyl, and R3 and R4 can be connected to form a fatty ring containing 3-10 carbon atoms. The synthesis method is short in steps, dangerous and expensive materials are not used, a reaction conversion rate is high, reaction time is short, and operation is easy and convenient. Production costs and post-treatment costs are reduced, and a cost advantage is obvious. The method can be widely used for preparing antiviral drugs of nirmatrelvir, boceprevir or narlaprevir, and has good market prospects.

专利号:EP-1919850-B1
优先权日:2005-08-11
标题:Nitro substituted alpha-olefin synthesis catalysts
发明人：ADELMAN DOUGLAS J; IONKIN ALEX SEREGY
权利人:DU PONT
摘要:Iron, cobalt, chromium or vanadium complexes of 2,6-pyridinedicarboxaldehydes diimines and 2,6-diacylpyridines diimines which are suitable for catalyzing the oligomerization of ethylene to alpha-olefins exhibit more prolonged catalytic activity if aryl groups attached to the imino carbon atom(s) are substituted with at least one nitro group.