CAS: 195387-29-2; 4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-1-Methyl-1H-Pyrrole-2-Carboxylic Acid

该化合物是一个化学化合物,其结构复杂,包括一个火花环和氟氧基碳酸(Fmoc)保护组.该化合物通常具有芳香化合物和热循环化合物的特性,有助于其稳定性和再活性.碳信箱酸功能组的存在表明它可以参与酸基反应,而磷酸合成组则经常用作氨酸的一种保护性混合物.该化合物很可能在有机溶剂中溶解,反映氟芳基化合物组的防水性质,并可能因其结构特征而在生物系统中出现特定的相互作用.其合成和应用与有机化学和药化学领域有关,特别是在药品和基于浸泡的治疗领域.

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CAS号335059-62-6 tert-butyl 4-[(... | CAS号110-71-4 乙二醇二甲醚 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号13138-78-8 1-甲基-4-硝基吡咯-2-羧酸 | CAS号45776-13-4 4-氨基-1-甲基-1H-2-吡咯甲酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号45776-13-4 4-氨基-1-甲基-1H-2-吡咯甲酸

合成工艺路线路线简述

  • 合成目标产物 4-(9H-Fluoren-9-Ylmethoxycarbonylamino)-1-Methyl-1H-Pyrrole-2-Carboxylic Acid 主要起始原料 1H-Pyrrole-2-Carboxylic Acid, 4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Methyl-, 1,1-Dimethylethyl Ester
  • (文献来源)合成步骤主要原料 1H-Pyrrole-2-Carboxylic Acid, 4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Methyl-, 1,1-Dimethylethyl Ester
📜1-甲基-4-硝基吡咯-2-羧酸置于palladium On Activated Charcoal 氢气,Sodium Carbonate,溶剂黄146体系中,用 甲醇,丙酮 用作溶剂,化学反应 28.0H,反应生成4-(Fmoc-氨基)-1-甲基-1H-吡咯-2-羧酸
参考文献:Synthesis Of An Fmocn-Methyl 1H-Pyrrole Amino Acid Pentafluoro-Phenol Ester
标题:Synthesis Of An Fmocn-Methyl 1H-Pyrrole Amino Acid Pentafluoro-Phenol Ester
摘要:A Derivative Of 4-Amino-N-Methyl 1H-Pyrroie-2-Carboxylic Acid Was Synthesized Which Is Suitable For Automated Solid Phase Fmoc Protocols.
Doi:10.1080/00397919908086056

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专利信息


专利号:US-7067622-B2
优先权日:2001-06-25
标题 :Method of the solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; IIDA HIROKAZU; SAITO ISAO; SAITO TAKASHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

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参考标题:4-Methyltrityl-Protected Pyrrole And Imidazole Building Blocks For Solid Phase Synthesis Of Dna-Binding Polyamides
作者:Benedikt Heinrich,Olalla Vázquez |发布日期:2020.1.17
摘要:Dna-Binding Polyamides Are Synthetic Oligomers Of Pyrrole/imidazole Units With High Specificity And Affinity For Double-Stranded Dna. To Increase Their Synthetic Diversity, We Report A Mild Methodology Based On 4-Methyltrityl (Mtt) Solid Phase Peptide Synthesis (Spps), Whose Building Blocks Are More Accessible Than The Standard Fmoc And Boc Spps Ones. We Demonstrate The Robustness Of The Approach By
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