CAS: 180468-41-1; (R)-Ethyl 1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate

相似化合物

180468-42-2 1035272-88-8 1353274-25-5

上下游产品

chloroformic acid ethyl ester (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 1-phenyl-3,4-dihydroisoquinoline N-phenethylbenzamide (3S)-1-azabicyclo[2.2.2]°Ct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (3R)-1-azabicyclo[2.2.2]°Ct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

📜1-苯基-3,4-二氢异喹啉置于sodium Tetrahydroborate,Potassium Carbonate体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 60.0H,反应生成(R)-1-苯基-1,2,3,4-四氢异喹啉-2-甲酸乙酯
参考文献:Synthesis And Antimuscarinic Properties Of Quinuclidin-3-Yl 1,2,3,4-Tetrahydroisoquinoline-2-Carboxylate Derivatives As Novel Muscarinic Receptor Antagonists
标题:Synthesis And Antimuscarinic Properties Of Quinuclidin-3-Yl 1,2,3,4-Tetrahydroisoquinoline-2-Carboxylate Derivatives As Novel Muscarinic Receptor Antagonists
摘要:In The Course Of Continuing Efforts To Develop Potent And Bladder-Selective Muscarinic M-3 Receptor Antagonists,Quinuclidin-3-Yl 1-Aryl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylate Derivatives And Related Compounds Were Designed As Conformationally Restricted Analogues Of Quinuclidin-3-Yl Benzhydrylcarbamate (8). Binding Assays With Rat Muscarinic Receptor Subtypes Revealed That The Quinuclidin-3-Yl 1-Aryl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylate Derivatives Showed High Affinities For The M3 Receptor,And Selectivity For The M3 Receptor Over The M-2 Receptor. Of These Derivatives,(+)-(1S,3'R)-Quinuclidin-3'-Yl 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylate Monohydrochloride (9B) Exhibited Almost The Same Inhibitory Activity Against Bladder Contraction To That Of Oxybutynin (1),And More Than 10-Fold Selectivity For Bladder Contraction Versus Salivary Secretion,Demonstrating That 9B May Be Useful For The Treatment Of Symptoms Associated With Overactive Bladder Without Having Side Effects Such As Dry Mouth.
Doi:10.1021/jm050099Q