CAS: 13794-72-4; 6,7-Dimethoxy-1H-Quinazolin-4-One

相似化合物

179688-52-9 162012-72-8 35241-23-7

上下游产品

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藜芦酸置于硫酸,Palladium On Activated Charcoal,氢气,硝酸体系中,用 甲醇,溶剂黄146 用作溶剂,化学反应生成6,7-二甲氧基喹唑啉-4-酮
参考文献:用于肿瘤 Pet 成像的具有低亲脂性的新型 F-18 标记喹唑啉衍生物的合成和评价
标题:用于肿瘤 Pet 成像的具有低亲脂性的新型 F-18 标记喹唑啉衍生物的合成和评价
摘要:四种具有低亲脂性的新型 18 F 标记喹唑啉衍生物,[18 F]4-(2-氟乙氧基)-6,7-二甲氧基喹唑啉 ([18 F]I),[18 F]4-(3-((4-(2-氟乙氧基)-7-甲氧基喹唑啉-6-基)氧基)丙基)吗啉([18 F]Ii),[18 F]4-(2-氟乙氧基)-7-甲氧基-6-(2-甲氧基乙氧基)喹唑啉 ([18 F]Iii) 和 [18 F]4-(2-氟乙氧基)-6,7-双(2-甲氧基乙氧基)喹唑啉 ([18 F]Iv) 通过两步放射合成程序合成总放射化学产率为 10% 至 38%(无衰减校正),放射化学纯度>98%.在体外测试了标记化合物的亲脂性和稳定性.4 种放射性示踪剂的 Log P 值范围从 0.52 到 1.07.然后我们进行了 Elisa 以测量它们对 Egfr-Tk 的亲和力;Elisa 测定结果表明,每种抑制剂均以剂量依赖性方式与 Egfr-Tk 特异性结合.[18
Doi:10.1002/jlcr.3538

专利信息

专利号:US-9452220-B2
优先权日:2014-12-23
标 题 :Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof
发明人：ZHANG YANMEI; DING KE; LIAO JINXI; WANG YICAN; CHEN PANYU
权利人:GUANGZHOU INST BIOMED & HEALTH
摘要:The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof: n n n n n n n n n n n n where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.

专利号:WO-2011147102-A1
优先权日:2010-05-28
标题 :Synthetic method for 6,7-substituents-4-aniline quinazoline
发明人：SHIH KAE-SHYANG; HSIEH YU-JUNG; LIU CHING-WEI
权利人:SHYANG JEN BIOTECH CO LTD; SHIH KAE-SHYANG; HSIEH YU-JUNG; LIU CHING-WEI
摘要:A method for the synthesis of 6,7-substituents-4-aniline quinazoline is disclosed, in which 3,4-substituted benzoic acid is used as a starting material and 6,7-substituents-4-aniline quinazoline is produced from it by esterification, O-alkylation, nitration, nitro group reduction, cyclization, and two-in-one reaction of chlorination and amine-substitution, or by esterification, O-alkylation or nitration, hydrolysis-demethylation, esterification, O-alkylation, nitro group reduction, cyclization, and two-in-one reaction of chlorination and amine-substitution.

专利号:CN-103923023-B
优先权日:2014-04-11
标 题 :A new method for microwave synthesis of gefitinib and its derivatives

专利号:US-6258820-B1
优先权日:1999-03-19
标题 :Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines

专利号:RU-2198879-C2
优先权日:1996-09-25
标题:Derivatives of quinazoline, methods of their synthesis, pharmaceutical compositions comprising thereof, method of attainment of antiangiogenic effect and/or effect of blood vessel permeability reduction in warm-blooded animal

专利号:US-2016175453-A1
优先权日:2014-12-23
标题 :Coupling compounds of nsaid anti-inflammatory and analgesic drugs and egfr kinase inhibitors, synthesis methods and applications thereof