CAS: 1190-53-0; 1-Butylbiguanide Hydrochloride

该化合物是一种口服抗血膜炎剂,主要用于二类糖尿病的治疗,主要用于二类糖尿病的治疗,其行动机制包括减少肝糖糖的生产,提高外围葡萄糖的摄入量,从而提高胰岛素的敏感性. 与其他重蛋酯相比,buformin 盐酸化物的半衰期较短,这可能会降低酸化的风险,这是该药物类的显著副作用. 它在降低节食血糖水平方面特别有效,对脂质代谢作用最小. 化合物在标准储存条件下保持稳定,并显示出良好的生物利用率,从而成为临床环境中控制血糖的可靠选择.

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334-18-9 101491-40-1 20351-28-4

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    📜二聚氰胺,正丁胺 反应生成盐酸丁福明
    参考文献:Suyamma,Takayuki
    标题:Suyamma,Takayuki

    海关参考信息

    专利信息


    专利号:EP-0901500-B1
    优先权日:1996-05-03
    标题:In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
    发明人:ZHANG ZHAODA; TANG JIN-YAN
    权利人:AVECIA BIOTECHNOLOGY INC
    摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under weakly acidic conditions. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

    专利号:EP-1546732-B1
    优先权日:2002-09-03
    标 题:Modulation of the synthesis of insulin
    发明人:WALTHER REINHARD
    权利人:UNIV ERNST MORITZ ARNDT
    摘要:The invention particularly relates to the use of substances, which modulate the activity of the proteins casein kinase II (CK II) and 14-3-3 epsilon and/or of the PcG protein EED or which influence the binding of the proteins casein kinase II (CK II) and 14-3-3 epsilon, of the PcG protein EED and/or of a fragment thereof with the protein pancreatic duodenal homeobox-1 (PDX-1) that plays a decisive roll in the glucose-induced biosynthesis of insulin, for influencing the synthesis of insulin or the provision of insulin.

    专利号:EP-1521826-B1
    优先权日:2002-06-14
    标题:A simple, efficient, and accelerated method for enzyme-catalyzed in vitro modification and synthesis of nucleic acid using microwave irradiation
    发明人:DAS RAKHA HARI; NAHAR PRADIP
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention relates to a simple, efficient, and accelerated method for enzyme-catalyzed in vitro modification and synthesis of nucleic acid using uninterrupted and brief microwave irradiation at a frequency ranging between 2300 to 2500 MHz, with the power output ranging between 600 to 900 watts, and for a period ranging from 5 to 120 seconds; and further, an apparatus for using said method.

    专利号:EP-0364340-B1
    优先权日:1988-10-05
    标题:Method for the synthesis of sulfonyl imides
    摘要:Method for the synthesis of sulfonylimidides having the formula M((RSO2)2N)y, whrein M is a metal or an ammonium radical quaternary or not, the Rs, which may be identical or similar are organic monovalent radicals, particularly hydrocarbyles and preferably perfluorohydrocarbyles, in C1 to C12, and y is the valence of M. On the one hand, a silazane component selected amongst the silazane compounds M(((R2)3Si)2N)y or the associations of a silazane derivative A((R2)3Si)2N or a fluoride M1Fz of low cross-linking energy is reacted with, on the other hand, at least one sulfonic halogenite component consisting of a sulfonyl fluoride RSO2F or in the association of a sulfonyl chloride RSO2Cl with a fluoride M1Fz, M, R and y having the above-mentionned significations, M1 being selected amongst the Ms and being optionally identical to M, z being the valence of M1 and R2 representing an alkyl in C1 to C4. The imidides obtained for which the R2 are perfluorated radicals and M is an alkaline metal such as Li are usable in association with polyethers for the production of materials of the ionic conduction type for all solid generators in thin films.

    专利号:EP-0356695-B1
    优先权日:1988-07-25
    标 题 :In vitro synthesis of an infectious RNA
    发明人:DUECHLER MARKUS; SKERN TIMOTHY DR; BLAAS DIETER DR; BERGER BERTHOLD DIPL-ING; SOMMERGRUBER WOLFGANG DR; KUECHLER ERNST PROF DR
    权利人:BOEHRINGER INGELHEIM INT
    摘要:The invention relates to the in vitro synthesis of an infectious RNA of HRV2 and ''full-size'' clones of HRV2.

    专利号:EP-1232226-B1
    优先权日:2000-09-08
    标题:Synthesis of nanoparticles
    发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKY CARSTEN; WELLER HORST; MEYSAMMY HEIKE; IBARRA FERNANDO
    权利人:NANOSOLUTIONS GMBH
    摘要:Production of inorganic nanoparticles that can be fluoresced consisting of a host material containing a dopant comprises using an organic solvent for liquid phase synthesis of the particles.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Liu B, Wang Z, He R, Xiong R, Li G, Zhang L, Fu T, Li C, Li N, Geng Q. Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway. Clin Sci (Lond). 2022 Feb 25;136(4):273-289. doi: 10.1042/CS20211156. 15(1):409-417. doi: 10.1515/biol-2020-0041.
    3: Bailey CJ. Metformin: historical overview. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. 28(9):923-932. doi: 10.1080/1061186X.2020.1729770. Epub 2020 Apr 21. 8(6):2705-15.
    6: Li J, Chen L, Liu Q, Tang M, Wang Y, Yu J. Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517. doi: 10.1080/15384047.2018.1433504. Epub 2018 Feb 27.

    合成参考文献


    摘要:Toksikologicheskii Vestnik., (2)(41), 1993
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