CAS: 1159-93-9; 2-Chloro-5-[2-(Dimethylamino)Ethyl]-11H-Benzo[b][1,4]Benzodiazepin-6-One

📜N-(4-Chloro-2-Iodo-Phenyl)-N-(2-Dimethylamino-Ethyl)-2-Nitro-Benzamide置于palladium Diacetate 铁粉,Caesium Carbonate,R-(+)-1,1'-联萘-2,2'-双二苯膦,溶剂黄146体系中,用 乙醇,甲苯 用作溶剂,化学反应 29.0H,反应生成氯苯西泮
参考文献:钯介导的二苯并[ B,E ] [1,4]二氮杂和苯并吡啶类似物的方法.篷布的有效合成
标题:钯介导的二苯并[ B,E ] [1,4]二氮杂和苯并吡啶类似物的方法.篷布的有效合成
摘要:已开发出一种合成二苯并[ B,E ] [1,4]二氮杂庚酮-11-酮和类似物吡啶并苯并二氮杂酮的合成途径.该方法依赖于(杂)芳基卤化物和适当的苯胺部分之间的分子内胺化过程.
Doi:10.1016/j.Tet.2004.10.061

专利信息

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:US-2008146526-A1
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:US-2009286759-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:WO-2008033572-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

专利号:US-7585996-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use