CAS: 105590-97-4; (S)-5-Benzyl 1-Tert-Butyl 2-Aminopentanedioate Hydrochloride

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上下游产品

CAS号1676-73-9 L-谷氨酸-γ-苄酯 | CAS号115-11-7 2-甲基丙烯

醋酸叔丁酯,L-谷氨酸 γ-苄酯置于高氯酸,Sodium Carbonate,盐酸体系中,用 乙醚,水 用作溶剂,以80%的收率获得l-谷氨酸-5-苄酯-1-叔丁酯盐酸盐
参考文献:一种谷氨酸-5-苄酯-1-叔丁酯盐酸盐的制备方法
标题:一种谷氨酸-5-苄酯-1-叔丁酯盐酸盐的制备方法
摘要:一种谷氨酸-5-苄酯-1-叔丁酯盐酸盐的制备方法,主要解决现有合成方法存在操作难度大的技术问题.本发明的技术方案:一种谷氨酸-5-苄酯-1-叔丁酯盐酸盐的制备方法,包括以下步骤:由谷氨酸为起始原料,同苯甲醇酯化并纯化得谷氨酸-5-苄酯,然后谷氨酸-5-苄酯在催化剂催化下同醋酸叔丁酯转酯反应得谷氨酸-5-苄酯-1-叔丁酯,最后用乙醚盐酸气调酸性制得谷氨酸-5-苄酯-1-叔丁酯盐酸盐.产品用于多肽合成领域.

专利信息

专利号:US-9802886-B2
优先权日:2012-05-15
标题 :Process for making lysine-glutamic acid dipeptide derivatives
发明人：PUENTENER KURT
权利人:HOFFMANN LA ROCHE
摘要:The invention relates to compounds of the formula n n n n n n n n n n n n and to a process for making same and to the use of the products in the solid phase peptide synthesis. The compounds of formula I are versatile peptide intermediates for the solid phase peptide synthesis (SPPS) of peptide drugs which comprise a Glu-fatty alkyl side chain building block attached to a Lys-part of the peptide chain.

专利号:CN-112915217-A
优先权日:2021-01-29
标题:A class of prodrugs targeted for prostate cancer and methods for their synthesis