CAS: 96702-03-3; (S)-2-Methyl-3,4,5,6-Tetrahydropyrimidine-4-Carboxylic Acid

相似化合物

89181-59-9 1909347-71-2 165542-15-4

上下游产品

N-γ-acetyl-L-2,4-diaminobutyrate

N-乙酰-L-天门冬酰胺置于sodium Tetrahydroborate,Potassium Tert-Butylate,Sodium Hydride,三乙胺,N,N'-二环己基碳二亚胺,Lithium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水,异丙醇 作为反应溶剂,化学反应 16.0H,反应生成 四氢嘧啶
参考文献:一种合成小分子氨基酸衍生物依克多因的方 法
标题:一种合成小分子氨基酸衍生物依克多因的方 法
摘要:本发明涉及一种小分子氨基酸衍生物(S)‑2‑甲基‑1,4,5,6‑四氢嘧啶‑4‑羧酸(依克多因)的合成方法,其特征是以廉价易得的商品化的l‑乙酰天冬酰胺为原料,先经过缩合成内酰胺,上保护,羰基还原,酰胺水解,氨基脱保护盐酸盐化再成环得到依克多因分子.该方法能够以很低的成本,较少的步骤方便的得到高纯度的(S)‑2‑甲基‑1,4,5,6‑四氢嘧啶‑4‑羧酸(依克多因)产品,反应条件温和,易于控制,环境污染很小,适合工业化生产.

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-8598346-B2
优先权日:2008-07-16
标 题 :Synthesis of cyclic amidines
发明人：LENTZEN GEORG; NEUHAUS THORSTEN
权利人:LENTZEN GEORG; NEUHAUS THORSTEN; BITOP AG
摘要:The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

专利号:US-9005895-B2
优先权日:2010-06-21
标题:Compositions, methods and kits for nucleic acid synthesis and amplification
发明人：WOO CORA L; BERKMAN JENNIFER; YIM PRISCILLA W
权利人:WOO CORA L; BERKMAN JENNIFER; YIM PRISCILLA W; LIFE TECHNOLOGIES CORP
摘要:The present invention is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in a one-step RT-PCR procedure comprising one or more agents used to increase tolerance to PCR inhibitors.

专利号:US-11629173-B2
优先权日:2017-08-29
标题 :Compositions and methods using methanotrophic S-layer proteins for expression of heterologous proteins
发明人：KALYUZHNAYA MARINA; DEMIDENKO OLEKSANDR
权利人:SAN DIEGO STATE UNIV SDSU FOUNDATION
摘要:In alternative embodiments, provided are compositions and methods for making a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. In alternative embodiments, the compositions and methods comprise recombinantly engineering a methylotrophic or methanotrophic bacteria to recombinantly express a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. Also provided are compositions and methods for displaying or immobilizing proteins on a methanotrophic S-layer. In alternative embodiments, provided are compositions and methods comprising recombinant methylotrophic or methanotrophic bacteria comprising assembled or self-assembled recombinant or isolated chimeric S-layer polypeptides. In alternative embodiments, provided are compositions and methods using recombinant methylotrophic or methanotrophic bacteria, optionally a Methylomicrobium alcaliphilum , optionally a M. alcaliphilum sp. 20Z, for ectoine ((4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid), for the production or synthesis of a protein, e.g., an ectoine, or an enzyme, e.g., a lipase.

专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.

专利号:US-2006269975-A1
优先权日:1999-07-16
标 题:Corynebacterium glutamicum genes encoding proteins involved in DNA replication, protein synthesis, and pathogenesis
发明人：POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR
权利人:BASF AG
摘要:Isolated nucleic acid molecules, designated RRP nucleic acid molecules, which encode novel RRP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing RRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated RRP proteins, mutated RRP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of RRP genes in this organism.