CAS: 71142-71-7; (S)-1-(D-Phenylalanyl)-N-((S)-1-Chloro-6-Guanidino-2-Oxohexan-3-yl)Pyrrolidine-2-Carboxamide

专利信息

专利号:US-6238875-B1
优先权日:1991-03-12
标题:Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1
发明人：ALTIERI DARIO C
权利人:SCRIPPS RESEARCH INST
摘要:A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. These new cell surface receptors are designated effector cell protease receptors (EPRs) and include EPR-1, which is shown to bind protease ligands. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention. n Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The receptors are also demonstrated to bind coagulation factor Xa, which binding is inhibited by various disclosed monoclonal antibodies to the receptors. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.

专利号:US-2011318421-A1
优先权日:2010-06-24
标 题:Surface functionalized ceramic nanoparticles
发明人：PARSONAGE EDWARD
权利人:PARSONAGE EDWARD
摘要:The present disclosure is directed to surface functionalized ceramic nanoparticles. The method for producing the surface functionalized ceramic nanoparticles generally includes at least four distinct steps: 1) synthesis of an amphiphilic surfactant having the desired surface functionality, 2) formation of mixed solvent microstructured solution with the surfactant, 3) synthesis of the desired ceramic within the microstructured solution, and 4) chemical attachment of the surfactant to the ceramic nanoparticle. The composition of the surface functionalized nanoparticle comprises a lipophilic component, a hydrophilic component, a chelating agent and a ceramic forming component.

专利号:US-2007160574-A1
优先权日:2000-04-12
标题 :Design of CXC chemokine analogs for the treatment of human diseases
发明人：MERZOUK AHMED; SALARI HASSAN
权利人:MERZOUK AHMED; SALARI HASSAN
摘要:The present invention generally relates to the design, preparation, derivation, and use of mimetics of CXC chemokines (CXCL1-CXCL17) in the prevention, treatment, and ameliorization of a wide variety of diseases and disorders. Generally speaking, this invention is directed to the design, synthesis, and use of chemokine analogs which bind to CXC chemokine receptors CXCR1-CXCR7, such that the analogs can be designed to affect the activity of the receptor, either as an agonist or an antagonist. The analogs can be useful for treating a wide variety of diseases and disorders, and can also serve as an adjunct to the treatment of a variety of diseases and disorders.

专利号:US-9034346-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; SYDNEY GREGORY T; GEITZ KURT; DAYTON PETER L; SAHATJIAN RONALD A
权利人:MILLER KATHLEEN M; SYDNEY GREGORY T; GEITZ KURT; DAYTON PETER L; SAHATJIAN RONALD A; BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.