CAS: 70360-12-2; Sideritoflavone

该化合物是一种主要来自某些植物来源的氟虫素化合物,特别是属于ferns家族的植物来源,该化合物的特点是其多酚结构,有助于其抗氧化性特性.侧面菜罗夫罗夫酮展示了一系列生物活动,包括潜在的抗炎和抗微生物影响,使其对药理研究感兴趣.其溶性特性可以不同,其有机溶剂的溶性往往比水更为溶解,许多氟虫类的典型特征就是水.此外,它可以与各种生物目标互动,影响细胞路径,并有可能提供治疗利益.侧面菜研究是对天然产品及其在医药和健康应用的广泛兴趣的一部分,特别是在传统草药疗法方面.随着研究的继续,预计会进一步深入了解其在健康和疾病管理方面的行动和潜在应用机制.

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MSDS等安全信息

上下游产品

3',4'-dihydroxy-5,6,7,8,-tetramethoxyflavone 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 3,4-dibenzyloxybenzoyl chloride 3',4'-Dibenzyloxy-5,6,7,8-tetramethoxyflavoneisoleucanthogenin Acetic acid 2-(3,4-diacetoxy-phenyl)-6,7,8-trimethoxy-4-oxo-4H-chromen-5-yl ester

合成工艺路线路线简述

    📜3',4'-Dibenzyloxy-5,6,7,8-Tetramethoxyflavone置于palladium On Activated Charcoal 三氯化铝,氢气体系中,用 乙腈 作为反应溶剂,化学反应 2.0H,反应生成 毒马草黄酮
    参考文献:Bhardwaj,D. K.; Gupta,A. K.; Jain,R. K.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 9,P. 800-801
    标题:Bhardwaj,D. K.; Gupta,A. K.; Jain,R. K.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 9,P. 800-801

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    专利信息


    专利号:US-2002165207-A1
    优先权日:2001-05-02
    标题 :Compositions and methods for the treatment of diabetic neuropathy
    发明人：ROSENBLOOM RICHARD
    摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

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    合成参考文献


    参考文献:10.1016/0031-9422(89)85071-x
    摘要:Wollenweber E, Stern S, Roitman JN, Yatskievych G. External leaf flavonoids of Polanisia trachysperma. Phytochemistry. 1989;28(1):303–5. doi: 10.1016/0031-9422(89)85071-x.
    参考文献:10.1016/s0031-9422(00)90948-8
    摘要:Tomas F, Ferreres F, Guirado A. 5,3′,4′-trihydroxy-6,7,8-trimethoxyflavone from Sideritis leucantha. Phytochemistry. 1979 Jan;18(1):185–6. doi: 10.1016/s0031-9422(00)90948-8.
    参考文献:10.1016/s0031-9422(00)90723-4
    摘要:Wu S, Zang H, Chen Y, Lin Z, Sun H. Diterpenoids from Isodon wikstroemioides. Phytochemistry. 1993 Nov;34(4):1099–102. doi: 10.1016/s0031-9422(00)90723-4.
    参考文献:10.1016/s0031-9422(00)81116-4
    摘要:Barberan F. An HPLC study of flavones from some Spanish Sideritis species. 1985;24(6):1285–8. doi: 10.1016/s0031-9422(00)81116-4.
    参考文献:10.1016/s0031-9422(00)84935-3
    摘要:Shimizu M, Ito T, Terashima S, Hayashi T, Arisawa M, Morita N, Kurokawa S, Ito K, Hashimoto Y. Inhibition of lens aldose reductase by flavonoids. Phytochemistry. 1984 Aug;23(9):1885–8. doi: 10.1016/s0031-9422(00)84935-3.
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