CAS: 6609-57-0; 2-Ethoxybenzonitrile

该化合物是属于芳烃硝酸酯类的有机化合物,其特征为:2-乙氧苯基苯基苯基,在正方形位置上,以乙氧基组(-OCH2CH3)和硝基苯基组(-CN)替换为乙氧基(-CN),该化合物一般没有色素,可视其纯度和温度而定,为黄色液体或固态;其特征为芳香性质,有助于其稳定性和再活动;硝酸酯组的存在具有极地特性,使其在极地溶剂中溶解,而非极地溶解剂中则较少溶解. 2-乙氧苯基硝基苯基,通常用作有机合成的中间体,特别是在制药和农用化学剂的生产中.其再活性可归因于硝酸组的含电磁性质,可影响芳基环的电荷替代反应.在处理该化合物时,应当采取安全防范措施,因为若含有,则会构成健康风险.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

2-ethoxy-benzaldehyde-oxime acetic anhydride ortho-phenitidine ethanol 2-ethoxybenzamide 2-ethoxybenzoic acid E,E)-bis-(2-ethoxy-benzylidene)-hydrazine(E,E)-bis-(2-ethoxy-benzylidene)-hydrazine 2-ethoxy-3,5-dinitro-benzonitrile

合成工艺路线路线简述

    2-乙氧基苯甲酰胺置于氢化钾,C39H21Mno6体系中,用 四氢呋喃,乙腈 作为反应溶剂,以95.5 %的收率获得产物2-乙氧基苯甲腈
    参考文献:Dehydration Of Amides By Redox‐active Phenalenyl Based Mn‐catalyst
    标题:Dehydration Of Amides By Redox‐active Phenalenyl Based Mn‐catalyst
    摘要:摘要 一种具有氧化还原活性的苯烯丙配体配位锰(iii)络合物可以通过化学还原反应生成一种含有配体中心自由基的活性催化剂.这种经化学还原的锰催化剂在温和条件下使用惰性廉价硅烷--聚甲基氢硅氧烷(pmhs)对多种伯胺(包括各种生物活性分子的后期多样化)进行硅烷化脱水合成腈类时,显示出极佳的催化反应活性.对照实验表明,本催化反应是由配体中心自由基引发的自由基途径.
    DOI:10.1002/cctc.202300462

    海关参考信息

    专利信息


    专利号:WO-2023237381-A1
    优先权日:2022-06-09
    标题:Process for the synthesis of polyethylenes or copolymers of ethylene and 1,3-diene having a terminal ketone function
    发明人:BOISSON CHRISTOPHE; D'AGOSTO FRANCK; DESGRANGES ARIANE; NGO ROBERT; JEAN-BAPTISTE-DIT-DOMINIQUE FRANÇOIS
    权利人:MICHELIN & CIE; CENTRE NAT RECH SCIENT; ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE LYON; UNIV CLAUDE BERNARD LYON
    摘要:The invention relates to a method for preparing a polyethylene having a terminal ketone function or a copolymer of ethylene and a 1,3-diene and optionally a vinyl aromatic compound which contains more than 50 mol% of ethylene and has a terminal ketone function; said method comprises a polymerization reaction of the monomers in the presence of a borohydrido-neodymocene complex and an organo-magnesium compound, followed by a coupling reaction with a compound having a nitrile function, and then a hydrolysis reaction.

    专利号:CN-119343386-A
    优先权日:2022-06-09
    标 题:Synthesis of polyethylene or copolymer of ethylene and 1, 3-diene having terminal ketone function

    专利号:US-7569606-B2
    优先权日:2006-01-26
    标 题 :Platinum complexes with mononitrile-containing ligands
    发明人:XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR
    权利人:BIONUMERIK PHARMACEUTICALS INC
    摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

    专利号:US-9351974-B2
    优先权日:2011-11-10
    标题 :Substituted pteridinones for the treatment of cancer
    发明人:JIN MEIZHONG; KADALBAJOO MRIDULA; LI AN-HU; MULVIHILL MARK J; SIU KAM W; STEINIG ARNO G; WANG JING
    权利人:OSI PHARMACEUTICALS LLC
    摘要:Compounds of Formula I, as shown below and defined herein: n npharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven or mediated at least in part by RSK. This Abstract is not limiting of the invention.

    专利号:CN-115043845-A
    优先权日:2022-07-20
    标 题 :Synthesis method of sildenafil

    专利号:CN-116332733-A
    优先权日:2023-03-30
    标题:A kind of synthesis technique of dapagliflozin intermediate
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    合成参考文献


    摘要:Subramanian, L. R., Science of Synthesis, (2004) 19, 118.
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