CAS: 65416-85-5; Ethyl 2-Amino-5-Isopropylthiophene-3-Carboxylate

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CAS号123418-51-9 5-异丙基噻吩-3-羧酸

📜氰乙酸乙酯,异戊醛置于吗啉,Sulfur体系中,用 乙醇 作为反应溶剂,化学反应 16.0H,反应生成 2-氨基-5-异丙基噻吩-3-甲酸乙酯
参考文献: Modified Proteins And Protein Degraders[fr] Protéines Modifiées Et Agents De Dégradation De Protéines
标题: Modified Proteins And Protein Degraders[fr] Protéines Modifiées Et Agents De Dégradation De Protéines
摘要:本文提供了结合或降解靶蛋白的化合物,药物组合物和方法.本文还提供了具有dna损伤结合蛋白1(ddb1)结合基团的化合物.其中一些实施例包括连接物.其中一些实施例包括靶蛋白结合基团.本文还提供了配体-Ddb1复合物.本文还提供了体内修饰的ddb1蛋白.

专利信息

专利号:US-7030240-B2
优先权日:2003-03-31
标 题:Piperidinylamino-thieno[2,3-d] pyrimidine compounds
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; REDDY SEKAR A; CHERUKU SRINIVASA RAO; MELE NDEZ ROSA E; SHARADENDU ANURAG; CHEN DONGLI; MARANTZ YAEL; SHACHEM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; KESAVAN VENKITASAMY; BAR-HAIM SHAY
权利人:PREDIX PHARMACEUTICALS HOLDING
摘要:The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno[2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.