CAS: 6216-63-3; Benzyl (S)-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate

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(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester 2-i-BuCbz-L-Pro-°CO2-i-Bu N-carbobenzyloxy-L-proline methyl ester benzyl chloroformate (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester (S)-1-Pyrrolidin-2-yl-methanol (2S)-2-(4-methylphenylsulfonyloxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester (S)-2-tert-Butoxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Methyl (4S)-4-Azido-4-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Butanoate置于palladium On Activated Charcoal Sodium Tetrahydroborate,Sodium Periodate,氢气,二异丁基氢化铝,碳酸氢钠,溶剂黄146体系中,用 甲醇,乙醇,正己烷,甲苯,Petroleum Ether 作为反应溶剂,-78.0~25.0 °C,101.33 Kpa 条件下,反应 129.5H,反应生成 Z-L-脯氨醇
参考文献:Enantiospecific Syntheses Of (R)-And (S)-Proline And Some Derivatives From D-Glucono-1,5-Lactone
标题:Enantiospecific Syntheses Of (R)-And (S)-Proline And Some Derivatives From D-Glucono-1,5-Lactone
摘要:描述了从之前报道的 D-赤式己酸酯 9 中基于碳水化合物的对映特异性合成 (R)-脯氨酸 1 和 (S)-脯氨酸 2.对衍生自酯 9 的适当活化的中间体进行叠氮取代反应,然后进行还原环化 (H2/pd-C),得到取代的吡咯烷 14 和 22,它们以常规方式转化为相应的 N-Cbz 衍生物 16 和 24.将这些物质进行轻度酸性水解,然后氧化(偏高碘酸钠),得到受保护的脯氨酸 3 和 4,进一步氧化(亚氯酸钠),然后催化氢解,得到脯氨酸 1 和 2. N-Cbz-脯氨醇衍生物还报道了图5和图6.
DOI:10.1039/a704915C

专利信息

专利号:US-7968734-B2
优先权日:2004-07-01
标 题 :Organocatalysts and methods of use in chemical synthesis
发明人：WANG WEI; WANG JIAN; LI HAO
权利人:STC UNM
摘要:The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.

专利号:US-2007244328-A1
优先权日:2004-07-01
标 题 :Organocatalysts and Methods of Use in Chemical Synthesis