CAS: 60573-88-8; Ibotenic Acid (Monohydrate)

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合成工艺路线路线简述

  • 合成目标产物 Ibotenic Acid Monohydrate 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
  • (文献来源)合成步骤主要原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
📜2-(3-(Benzyloxy)-1,2-Oxazol-5-yl)Acetic Acid置于palladium On Activated Charcoal 盐酸,亚硝酸丁酯,氢气,Sodium Hydride,三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 2.41H,反应生成 鹅膏氨酸
参考文献:Madsen,Ulf; Brehm,Lotte; Krogsgaard-Larsen,Povl,Journal Of The Chemical Society. Perkin Transactions I,1988,P. 359-364
标题:Madsen,Ulf; Brehm,Lotte; Krogsgaard-Larsen,Povl,Journal Of The Chemical Society. Perkin Transactions I,1988,P. 359-364

海关参考信息

专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP. Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10. doi: 10.1002/cne.21685.
3: Hansson E. Metabotropic glutamate receptor activation induces astroglial swelling. J Biol Chem. 1994 Sep 2;269(35):21955-61.

合成参考文献


参考文献:10.1007/s00414-011-0599-9
摘要:Stříbrný J, Sokol M, Merová B, Ondra P. GC/MS determination of ibotenic acid and muscimol in the urine of patients intoxicated with Amanita pantherina. International Journal of Legal Medicine. 2011 Jul 13;126(4):519–24. doi: 10.1007/s00414-011-0599-9.
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