CAS: 530441-95-3; (R)-1-(1-(Bromomethoxy)Ethyl)-3,5-Bis(Trifluoromethyl)Benzene

该化合物是一种有机化合物,其结构复杂,包括一个溴甲基苯基组和苯环上的多三氟甲基替代物.溴甲基苯基组的存在表明,该化合物可能具有烷基卤化物的反活动特征,有可能参与核生殖替代反应.三氟甲基组以其电子提取特性而著称,这可显著影响化合物的再活动性和稳定性.鉴于多种电阴性原子的存在,这种化合物在室温度下很可能是固态的,可以促进分子间相互作用.此外,1R配置显示,该化合物可能表现出可能影响其生物活动或与其他分子互动的特定空间安排.

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上下游产品

formaldehyd (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 3,5-bis(trifluoromethyl)phenyl methyl ketone (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one (3R,5S,8aR)-5-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile (S)-2-amino-3-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-N-methyl-2-phenylpropionamide (R)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-4-phenyl-imidazolidin-2-one

合成工艺路线路线简述

    📜3,5-双三氟甲基苯乙酮置于c52H67Clirn2P,Potassium Tert-Butylate,氢气体系中,用 乙醇 作为反应溶剂,20.0~30.0 °C,5.07 Mpa 条件下,反应 8.83H,反应生成 (R)-1-(1-(溴甲氧基)乙基)-3,5-二(三氟甲基)苯
    参考文献:δ-酮酸酯的催化不对称加氢:手性1,5-二元醇的高效方法
    标题:δ-酮酸酯的催化不对称加氢:手性1,5-二元醇的高效方法
    摘要:高周转率:使用手性螺铱催化剂(R)-1实现了δ-芳基-δ-酮酸酯的高效催化不对称加氢反应.获得的手性1,5-二醇产品具有出色的对映选择性和周转率(tons)高达10万.tof =周转频率.
    DOI:10.1002/anie.201303011

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    专利信息


    专利号:US-9822116-B2
    优先权日:2008-09-05
    标 题:Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
    发明人：WU GEORGE G; WERNE GERALD; FU XIAOYONG; ORR ROBERT K; CHEN FRANK XING; CUI JIAN; SPRAGUE VICTORIA M; ZHANG FUCHENG; XIE JI; ZENG LIANSHENG; CASTELLANOS LOUIS PETER; CHEN YUYIN; POIRIER MARC; MERGELSBERG INGRID
    权利人:OPKO HEALTH INC
    摘要:This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

    专利号:US-2014031549-A1
    优先权日:2008-09-05
    标题:Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds

    专利号:US-2016145256-A1
    优先权日:2008-09-05
    标题:Process and intermediates for the synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

    专利号:US-9249144-B2
    优先权日:2008-09-05
    标题:Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

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    合成参考文献


    摘要:Benneche, T., Science of Synthesis, (2007) 29, 169.
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