CAS: 52411-34-4; 1,2-Bis(O-Aminophenoxy)Ethane

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CAS号51661-19-9 1,2-双(2-硝基苯氧基)乙烷 | CAS号88-75-5 邻硝基苯酚 | CAS号824-39-5 邻硝基苯酚钠 | CAS号102236-25-9 1-(2-氯乙氧基)-2-硝基苯 | CAS号67499-49-4 N-[2-[2-(2-acet... | CAS号85233-19-8 1,2-双(2-氨基苯氧基)乙... | CAS号73630-07-6 1,2-双(2-氨基苯氧基)乙... | CAS号67499-49-4 N-[2-[2-(2-acet...

硝苯酚置于palladium On Activated Charcoal,氢气,Potassium Carbonate体系中,用 乙醇 作为反应溶剂,化学反应生成 2,2'-二氨基乙二醇二苯醚
参考文献:水溶性,氧化还原活性有机金属钙螯合剂†
标题:水溶性,氧化还原活性有机金属钙螯合剂†
摘要:本文介绍了一系列新的有机金属水溶性螯合剂,它们结合了氧化还原部分(二茂铁)和由乙炔桥隔开的选择性ca 2+螯合剂(bapta).我们报告的合成和表征bapta螯合剂的有机金属衍生物的特点(一2A)和两个二茂铁基(2B)部分.这些螯合剂的单晶x射线结构分析表明,二茂铁基取代基相对于bapta单元的苯环具有意想不到的构象.在二茂铁基-乙炔基-Bapta分子的模型系统上进行dft计算,以评估在固态实验中观测到的两个限制性构象之间的能量分离,并检查结合口袋和氧化还原探针之间的有效电子通讯.通过uv-Vis和循环伏安法检测,2A-b对ca 2+的结合亲和力显示出在金属离子存在下的不同行为,具体取决于bapta是否被一个或两个二茂铁基团取代.
DOI:10.1039/c2Dt31830J

专利信息

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.

专利号:WO-2024097788-A1
优先权日:2022-11-01
标 题 :Glycosyltransferase engineering for chemoenzymatic total synthesis of gangliosides
发明人：GUCCHAIT ARIN; CHEN XI; YU HAI; ZHANG LIBO
权利人:UNIV CALIFORNIA; GUCCHAIT ARIN
摘要:Described herein are Campylobacter jejuni β1–4GalNAcT (CjCgtA) variants comprising a polypeptide having at least 80% identity to the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2. Also described herein are Campylobacter jejuni β1–3-galactosyltransferase (CjCgtB) variants comprising a polypeptide having at least 80% identity to the amino acid sequence set forth in SEQ ID NO: 3. Optionally, in the CjCgtA and CjCgtB variants, the N-terminus of the polypeptide is fused to a maltose binding protein. Further described herein is a method for preparing a glycosylated molecule, comprising: forming a reaction mixture comprising (i) a glycosylation donor comprising a sugar component; (ii) a glycosylation acceptor comprising a sphingosine moiety; and (iii) a glycosyltransferase, wherein the glycosyltransferase is a CjCgtA variant as described herein or a CjCgtB variant as described herein; and maintaining the reaction mixture under conditions suitable for forming a glycosylated molecule.

专利号:WO-2023183781-A2
优先权日:2022-03-20
标 题:Legionaminic acid glycosyltransferases for chemoenzymatic synthesis of glycans and glycoconjugates

专利号:US-11572548-B2
优先权日:2015-12-18
标题 :Reaction mixture for synthesis of alpha1-2-fucosides
发明人：CHEN XI; ZHAO CHAO; YU HAI
权利人:UNIV CALIFORNIA
摘要:α1-2-fucosyltransferases, and methods and compositions for making and using α1-2-fucosyltransferases, are described herein.

专利号:US-11279959-B2
优先权日:2017-05-03
标题:Methods and enzyme catalysts for the synthesis of non-canonical amino acids