CAS: 51767-39-6; N-(4-Hydroxyphenyl)Methanesulfonamide

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CAS号141626-36-0 决奈达隆 | CAS号1375149-24-8 4-(methylsulfon... | CAS号73021-84-8 N-(4-ox°Cyclohe...

📜N-(4-Fluorophenyl)Methanesulfonamide置于2-丁炔-1-醇,Potassium Tert-Butylate体系中,用 二甲基亚砜 作为反应溶剂,化学反应 0.25H,反应生成 阿苯达唑亚砜
参考文献:选择性小分子神经肽y Y2受体拮抗剂的合成及合成孔径雷达
标题:选择性小分子神经肽y Y2受体拮抗剂的合成及合成孔径雷达
摘要:报告了高效和选择性的小分子神经肽 Y Y2 受体拮抗剂.从 Hts 鉴定的命中分子n-(4-Ethoxyphenyl)-4-[hydroxy(Diphenyl)Methyl]Piperidine-1-Carbothioamide的系统 Sar 探索导致发现了高效的 Npy Y2 拮抗剂16 (Cym 9484)和54 (Cym 9552),Ic 50值分别为 19 Nm 和 12 Nm.
DOI:10.1016/j.Bmcl.2012.04.107

专利信息

专利号:FR-2973027-A1
优先权日:2011-03-24
标题 :PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES

专利号:FR-2973028-A1
优先权日:2011-03-24
标 题:PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES

专利号:US-8796489-B2
优先权日:2010-03-02
标题 :Ketobenzofuran derivatives, method for synthesizing same, and intermediates
发明人：BAILLY FRÉDÉRIC; GRIMAUD BERNARD; MALEJONOCK IRINA; VAYRON PHILIPPE
权利人:BAILLY FRÉDÉRIC; GRIMAUD BERNARD; MALEJONOCK IRINA; VAYRON PHILIPPE; SANOFI SA
摘要:The present disclosure relates to ketobenzofuran derivatives of the general formula (I): n nas well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

专利号:KR-20140015483-A
优先权日:2011-03-24
标 题:Synthesis method of keto benzofuran derivative