CAS: 441044-12-8; (2S,4S)-1-[(Tert-Butoxy)Carbonyl]-4-Hydroxypiperidine-2-Carboxylic Acid
该化合物是一种手性管状衍生物,由4级的氢氧化物组和2级的碳球里酸混合物组成,由氮的三丁基碳基(Boc)组加以保护.该化合物是有机合成中有价值的中间体,特别是在制药和生物活性分子的制作方面.该混合物组确保选择性的再活动,而氢氧和碳箱里功能则具有多功能性变异潜力.其立体化学纯度为适合不对称合成,便于精确控制分子配置.该化合物因其稳定性和与标准的组合条件相容性,通常用于浸泡化学和药用化学研究.
- 英文名称(2S,4S)-1-[(Tert-Butoxy)Carbonyl]-4-Hydroxypiperidine-2-Carboxylic Acid
- 中文名称(2S,4S)-1-(叔丁氧羰基)-4-羟基哌啶-2-羧酸
- IUPAC名称(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid
- 其它别名(2S,4S)-1-(Tert-Butoxycarbonyl)-4-Hydroxypiperidine-2-Carboxylic Acid; Gcazzufidgxtda-Jammhhfisa-N; 1,2-Piperidinedicarboxylic Acid, 4-Hydroxy-, 1-(1,1-Dimethylethyl) Ester, (2S,4S)-; (2S,4S)-1-Boc-4-Hydroxy-Piperidine-2-Carboxylic Acid; (2S,4S)-N-Boc-4-Hydroxypiperidine-2-Carboxylic Acid; (2S,4S)-Boc-4-Hydroxypiperidine-2-Carboxylic Acid
- CAS编号441044-12-8
- MFCD编号:MFCD22689383
- 分子式:C11H19NO5分子量:245.27
- 产品CID: 1450182
- 产品分类有机原料→分子砌块→脂肪杂环类化合物→哌啶类化合物
相似化合物
321744-26-7 187753-13-5 653589-47-0上下游产品
tert-butyl dicarbonatedi-tert-butyl dicarbonate (2S,4S)-4-hydroxy-2-piperidinecarboxylic acid N-Acetyl-α-allylglycine (S)-2-(benzyloxycarbonylamino)pent-4-enoic acid 1-(tert-butyl) 2-methyl (2S,4S)-4-hydroxypiperidine-1,2-dicarboxylate (2S,4S)-N-((S)-1-cyano-2-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)ethyl)-4-hydroxypiperidine-2-carboxamide合成工艺路线路线简述
📜N-Cbz--L-烯丙基甘氨酸 在 盐酸,氯化亚砜,Lipase Ay30 From Candida Rugosa,三乙胺体系中,用 水作为反应溶剂,获得 (2S,4S)-N-BOC-4-Hydroxypiperidine-2-Carboxylic Acid
参考文献:水解酶在合成环状氨基酸中的用途
标题:水解酶在合成环状氨基酸中的用途
摘要:描述了具有所有必要结构特征以使其成为用于药物化学的理想支架的几种环状氨基酸的合成.每个合成过程中的关键步骤是使用水解酶来定义手性中心.为了将这些结构单元详细化为更复杂的分子,使用了结晶和不对称氢化来定义进一步的立体中心.
Doi:10.1016/J.Tet.2003.10.116
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399002-1,4-丁二醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
