CAS: 439858-21-6; (S)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine
该化合物是一种化学化合物,其特点是含有两个氮原子的六人环,由六人组成的环组成,含有两个氮原子,该化合物具有一个助其潜在生物活动(S)配置的手性中心,它具有一个4-氯联苯组和附属于氟他林的一个苯组,这增加了其亲性,有可能影响其与生物目标的相互作用.该化合物可能具有多种药理特性,因此对医药化学感兴趣.其结构复杂性使得与受体或酶发生多种相互作用,从而可能导致治疗应用.此外,氯化芳香环可能会影响化合物的稳定性和再活动性.与许多管状物衍生物一样,它可能因其对...
- 英文名称(S)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine
- 中文名称(S)-1-[(4-氯苯基)苯甲基]哌嗪
- IUPAC名称(S)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
- 其它别名(S)-(+)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine; Meclizine Impurity 9; Piperazine, 1-[(S)-(4-Chlorophenyl)Phenylmethyl]-; Cetirizine Impurity 39; (S)-1-(P-Chlorobenzhydryl)Piperazine; Cinnarizine Impurity 22; (S)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine? (Cetirizine Impurity）
- CAS编号439858-21-6
- MFCD编号:MFCD08235114
- FDA UNII编号:PW8N1I3GWE
- 分子式:C17H19ClN2分子量:286.8
- 产品CID: 1449534
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
CAS号2018-61-3 N-乙酰-L-苯丙氨酸 | CAS号303-26-4 1-(4-氯二苯基)哌嗪 | CAS号1198162-46-7 (-)-1-[(4-chlor... | CAS号104-88-1 对氯苯甲醛 | CAS号336105-23-8 (R)-(-)-N-[(1E)... | CAS号100-52-7 苯甲醛 | CAS号186249-76-3 (RS,E)-N-benzyl... | CAS号439695-63-3 (RS,S)-(1-(4-ch... | CAS号163837-58-9 (S)-1-((4-chlor...合成工艺路线路线简述
📜(S)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine Oxalate置于sodium Hydroxide体系中,用 正庚烷,水 作为反应溶剂,化学反应 2.0H,反应生成 (S)-1-[(4-氯苯基)苯甲基]哌嗪
参考文献: Processes For The Synthesis Of Levocetirizine And Intermediates For Use Therein[fr] Procédés De Synthèse De Lévocétirizine Et Intermédiaires Pour Une Utilisation Dans Ceux-Ci
标题: Processes For The Synthesis Of Levocetirizine And Intermediates For Use Therein[fr] Procédés De Synthèse De Lévocétirizine Et Intermédiaires Pour Une Utilisation Dans Ceux-Ci
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2921211000-乙二胺
2903991000-对氯甲苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).
专利号:RU-2118320-C1
优先权日:1993-03-15
标 题:Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]- -piperazine, method of their synthesis, method of synthesis of enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine derivatives
专利号:US-2011184174-A1
优先权日:2008-06-02
标题 :Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein
专利号:WO-2009147389-A2
优先权日:2008-06-02
标题:Processes for the synthesis of levocetirizine and intermediates for use therein
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/acs.jmedchem.5b00752
摘要:He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. J. Med. Chem. 2016 Feb 01;59(3):841–53. doi: 10.1021/acs.jmedchem.5b00752.
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