CAS: 401-95-6; 3,5-Bis(Trifluoromethyl)Benzaldehyde

上下游产品

CAS号785-56-8 3,5-双(三氟甲基)苯甲酰氯 | CAS号32707-89-4 3,5-二(三氟甲基)苯甲醇 | CAS号27126-93-8 3,5-双(三氟甲基)苯甲腈 | CAS号328-70-1 1,3-双(三氟甲基)-5-溴苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1002717-47-6 1,2-bis(3,5-bis... | CAS号725-89-3 3,5-双(三氟甲基)苯甲酸 | CAS号175135-01-0 2-苯氧基吡啶-3-碳酰肼 | CAS号402-31-3 间二三氟甲苯 | CAS号107337-73-5 3,5-(CF3)2C6H3Li | CAS号1054543-47-3 凋亡激活因子VII,热休克蛋白... | CAS号109086-18-2 2-[3,5-bis(trif... | CAS号32707-89-4 3,5-二(三氟甲基)苯甲醇 | CAS号511256-36-3 (S)-N-甲基-1-[3,5... | CAS号184888-50-4 1-[3,5-bis(trif... | CAS号184969-49-1 3,5-双(三氟甲基)肉桂酸乙酯 | CAS号85068-34-4 3',5'-双(三氟甲基)苯乙酮 | CAS号225920-05-8 (S)-1-[3,5-二(三氟... | CAS号85068-29-7 3,5-双(三氟甲基)苯甲胺 | CAS号1027096-75-8 1,1-bis(trimeth...

3,5-双三氟甲基苄醇置于吡啶,氧气,Palladium Diacetate体系中,用 甲苯 作为反应溶剂,100.0 °C,3.55 Mpa 条件下,反应 2.5H,以91%的收率获得产物3,5-双三氟甲基苯甲醛
参考文献:开发用于钯催化有氧氧化反应的安全且可扩展的连续流方法
标题:开发用于钯催化有氧氧化反应的安全且可扩展的连续流方法
摘要:的合成范围和效用 钯-催化有氧 氧化 反应在过去十年中取得了显着进展,这些反应有可能解决重要的绿色化学挑战 制药行业.然而,这种潜力尚未实现,因为安全问题和工艺限制阻碍了这种化学物质的大规模应用.这些限制通过连续流动管式反应器的开发得到解决,该反应器已在好氧反应器的多个规模上得到证明.氧化的酒精.稀释剂的使用氧气源(8% O 2 In N 2)确保氧/有机混合物永远不会进入爆炸状态,高效的气液 混合 在反应器中最小化 分解 同质的 催化剂 进入不活跃状态 钯金属.这些结果为大规模实施钯-催化(和其他)有氧 氧化 反应 制药 合成.
DOI:10.1039/c0Gc00106F

专利信息

专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人：FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:WO-2014037963-A1
优先权日:2012-09-06
标 题 :A PROCESS FOR THE SYNTHESIS OF β, Æ´ UNSATURATED KETONES
发明人：MHASKE SANTOSH BABURAO; AHIRE MILIND MUKUND
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose Pd/ N -Heterocyclic carbene catalyzed one step process for synthesis of β, Æ´-unsaturated ketones by direct acylation of allylic Carbons with aldehydes.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-6045755-A
优先权日:1997-03-10
标题 :Apparatus and method for combinatorial chemistry synthesis
发明人：LEBL MICHAEL; POKORNY VIT; KRCHNAK VIKTOR
权利人:TREGA BIOSCIENCES INC
摘要:In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels. In alternative embodiments, this invention includes these work-stations, tools, reaction vessels and reaction vessel arrays in various combinations or sub-combinations either for use in partially integrated robots or for manual or standalone use.

专利号:US-2022064167-A1
优先权日:2018-05-17
标 题 :Imidazo-pyrazole carboxamide derivatives as anticancer agents and the synthesis thereof
发明人：DEMJÉN ANDRÃ?S; Puskás László; KANIZSAI IVAN; SZEBENI GÃ?BOR; ANGYAL ANIKÓ; GYURIS Márió; Hackler László
权利人:AVIDIN KFT
摘要:The present invention relates to novel imidazo[1,2-b]pyrazole carboxamide and carbothioamide derivatives of general formula (V), and the advantageous derivatives and pharmaceutically acceptable salts thereof, the synthesis thereof, and medicinal and/or pharmaceutical composition comprising these compounds thereof and synthesis thereof, and for use as a medicament, for use in the treatment of different diseases, advantageously of cancer. The subject compounds are advantageously for use in the treatment of solid malignancies, advantageously breast, lung, melanoma, gliomas, and myeloproliferative and myelodysplastic neoplasms, acute myelogenous/myeloid leukemias and colon cancer by the differentiation and subsequent apoptosis of pre-matured myeloid leukemic cells or myeloid-derived suppressor cells and/or by direct effect on solid tumors.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.