CAS: 394-31-0; 2-Amino-5-Hydroxybenzoic Acid

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CAS号1953-54-4 5-羟基吲哚 | CAS号99-06-9 3-羟基苯甲酸 | CAS号610-37-7 5-羟基-2-硝基苯甲酸 | CAS号552-16-9 2-硝基苯甲酸 | CAS号579-73-7 Benzoic acid, 2... | CAS号582-61-6 benzoylazide | CAS号50727-06-5 5-羟基异二氢吲哚-1,3-二酮 | CAS号107920-24-1 5-hydroxy-2-p-t... | CAS号110846-17-8 5-hydroxy-2-[(4... | CAS号54413-93-3 2-碘-5-甲氧基苯甲酸 | CAS号490-79-9 2,5-二羟基苯甲酸 | CAS号340291-79-4 2-(Acetylamino)... | CAS号50424-28-7 4-氯-6-甲氧基喹唑啉 | CAS号179246-11-8 4-氯喹唑啉-6-基 乙酸酯 | CAS号244765-00-2 2-叔丁氧基羰氨基-5-羟基苯甲酸 | CAS号1882-72-0 2-氨基-5-羟基苯甲酸甲酯 | CAS号56961-30-9 2-氯-5-羟基苯甲酸 | CAS号58380-11-3 2-溴-5-羟基苯甲酸

5-羟基吲哚置于ruthenium Trichloride,四氧化锇,Bromamine B,Sodium Hydroxide体系中,用 水,乙腈 用作溶剂,化学反应 4.33H,以96%的收率获得2-氨基-5-羟基苯甲酸
参考文献:钌和催化邻氨基苯甲酸合成的机理及催化作用
标题:钌和催化邻氨基苯甲酸合成的机理及催化作用
摘要:钌,和钌+催化的合成方法已开发出来,用于在313 K的碱性乙腈-水(1:1)中使用溴胺b从吲哚以非常好或极佳的收率合成吲哚类邻氨基苯甲酸.详细的钌,催化研究并将两者的混合物进行合成反应.在很大程度上观测到ru(III)+ Os(viii)的正协同催化活性,其活性大于其单独催化活性的总和.对每种催化反应进行了详细的动力学和机理研究.发现每种催化反应的动力学模式和机理图对于每种催化剂都是不同的,并且遵守基本的速率定律: 其中,X,Y <1.在不同温度下研究反应,并评估每种催化反应的活化参数.在相同的实验条件下,将所有三个催化反应的动力学与未催化反应进行了比较,发现催化反应的速度提高了6到42倍.上述催化剂的催化效率遵循以下顺序:Ru(III)+ Os(viii)> Os(viii)> Ru(III).这种趋势可能归因于催化剂的不同d电子构型.所提出的机理和严格的动力学模型得出的结果与每个催化反应
Doi:10.1002/aoc.1685

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2025313551-A1
优先权日:2022-12-15
标题 :Process for the preparation of a quinazolinone derivative
发明人：DOTT PASCAL JEAN CLAUDE; FANTASIA SERENA MARIA; GUILLEMOT-PLASS MAUD; KALDRE DAINIS; LARI GIACOMO MARCO; MODOLO-CHELLAT ISABELLE GEORGETTE HUGUETTE; SEDELMEIER JOERG MATHIAS; TROKOWSKI SEBASTIAN
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a new process for the preparation of (3R)—N-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale.

专利号:US-11872245-B2
优先权日:2015-07-24
标 题:Antiseptic polymer and synthesis thereof
发明人：FATHI ALI; DEHGHANI FARIBA
权利人:TRIMPH IP PTY LTD
摘要:According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

专利号:US-7071145-B2
优先权日:2001-09-25
标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material
发明人：MORITA MITSUNOBU; HAYAKAWA KUNIO; TORII MASAFUMI; NARUSE MITSURU
权利人:RICOH KK
摘要:A thermosensitive recording material comprising a thermosensitive layer provided on a substrate, and the thermosensitive layer comprises as main ingredients a leuco dye and a developer to make colored state of said leuco dye when heated, wherein the developer is an oligomer composition obtained from the reaction of a polyvalent isocyanate compound represented by following Formula (I) with an aromatic amine represented by following Formula (II); n nwhere X represents a try- or more-valent group, a represents an integer numeral of 3 or more, b and c represent respectively integer numerals in the range of 0 to 5 and they satisfy a relation of b+c=1 to 5, Z represents hydrogen atom, alkyl group, allyl group or aryl group, and the aryl group may include condensed ling structure thereof, and d represents an integer numeral in the range of 0 to 4. This developer shows excellent reliabilities of both image and background area, and also shows an excellent color-developing characteristics (color developing sensitivity and image density).

专利号:US-2022047711-A1
优先权日:2018-12-10
标题 :Photocrosslinking peptides for site specific conjugation to fc-containing proteins
发明人：SADOWSKY JACK; ZACHARIAS NEELIE TYANA
权利人:GENENTECH INC
摘要:Provided herein are peptides having a photocrosslinking moiety useful for the synthesis of antibody-drug conjugates as well as methods of making and using such conjugates.

专利号:US-2003153460-A1
优先权日:2001-09-25
标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material