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CAS号63228-62-6 N-(3-硝基苯基)甲烷磺酰胺 | CAS号99-09-2 间硝基苯胺 | CAS号57004-73-6 2-[3-(methanesu...

N-(3-硝基苯基)甲烷磺酰胺置于tin(II) Chloride Dihdyrate体系中,用 乙醇 作为反应溶剂,化学反应 16.0H,反应生成 3-甲磺酰氨基苯胺
参考文献:探索2H-吲唑作为sgk1,Tie2和src激酶抑制剂的模板.
标题:探索2H-吲唑作为sgk1,Tie2和src激酶抑制剂的模板.
摘要:新型脚手架的更广泛和系统的应用常常因缺乏短而可靠的合成通道而受阻.我们研究了一种设计和合成一系列n2取代的aza-2H-吲唑衍生物作为潜在激酶抑制剂的新策略.在合理的配体比对方法的指导下,对迄今代表性不足的aza-2H-吲唑支架进行鉴定,将吲唑在n2位与苯基间隔基和芳基磺酰胺或酰胺键连接.针对30种激酶的初步分析证实了计算机预测的选择性偏倚.合成的52个不同的aza-2H-吲唑衍生物的聚焦文库显示出对sgk1,Tie2和src激酶的非常好初始选择性抑制作用,最佳代表的ic50值在500 Nm范围内.
DOI:10.1002/cmdc.201900328

专利信息

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.