CAS: 35120-10-6; (Methylthio)Acetonitrile

该化合物是一种多用途有机硫化合物,配有分子式C3H5NS.该化合物的特点是靠近甲基硫磷(-SCH3)的活性硝化物组,使其成为有机合成中有价值的中间体.该化合物由于能够进行核循环替代和循环反应,对于编制异性循环,药品和农用化学品特别有用.在标准条件下,其中度的挥发性和稳定性有利于实验室和工业环境中的处理. (甲基乙基硫)丙烯还被用于合成硫醚衍生物,并用作含硫化精细化学品的建筑块.建议在冷干条件下适当储存,以保持纯度.

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2444-37-3 22551-24-2 53250-09-2

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-(methylthio)acetamide methylthiol chloroacetonitrile sodium thiomethoxide methanesulfinyl-acetonitrile methanesulfonyl-acetonitrile 2-Methylsulfanyl-acetimidic acid methyl ester acetonitrileα-2-Nitro-5-(methylthio)phenylacetonitrile

合成工艺路线路线简述

    📜2-(甲硫基)乙酰胺置于phosphorus Pentoxide体系中,化学反应生成(甲基硫代)乙腈
    参考文献:Kiprianow; Ssytnik; Ssytsch,Zhurnal Obshchei Khimii,1936,Vol. 6,P. 582
    标题:Kiprianow; Ssytnik; Ssytsch,Zhurnal Obshchei Khimii,1936,Vol. 6,P. 582

    海关参考信息

    专利信息


    专利号:US-4388310-A
    优先权日:1982-03-01
    标 题:6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids
    发明人:CHRISTENSEN BURTON G; DININNO FRANK P; MUTHARD DAVID A; RATCLIFFE RONALD W
    权利人:MERCK & CO INC
    摘要:Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: I wherein: R1 is H or acyl; R2 is hydrogen or methoxyl; R3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/s004250000420
    摘要:Vorwerk S, Biernacki S, Hillebrand H, Janzik I, Müller A, Weiler EW, Piotrowski M. Enzymatic characterization of the recombinant Arabidopsis thaliana nitrilase subfamily encoded by the NIT2/NIT1/NIT3-gene cluster. Planta. 2001 Mar;212(4):508–16. doi: 10.1007/s004250000420.
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