CAS: 32752-54-8; (4-(Bromomethyl)Phenyl)(Phenyl)Methanone

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CAS号21192-61-0 2-(4-benzoylphe... | CAS号611-95-0 4-苯甲酰苯甲酸 | CAS号13991-01-0 [4-[(dimethylam... | CAS号1503-49-7 4-苯甲酰基苯腈 | CAS号114496-48-9 (4-benzoylpheny... | CAS号26077-80-5 (4-Benzoylpheny... | CAS号20912-50-9 4-苯甲酰基苯甲醛 | CAS号73603-46-0 N-(4-[BENZOYL]B... | CAS号74386-45-1 (4-benzoylpheny... | CAS号81449-01-6 甲酮, [4-(羟甲基)苯基]苯基-

📜4-甲基二苯甲酮置于四氯化碳,N-溴代丁二酰亚胺(Nbs)体系中,用81%的收率获得产物4-(溴甲基)二苯甲酮
参考文献:单酰基甘油脂肪酶的可逆和选择性抑制剂可缓解多发性硬化症.
标题:单酰基甘油脂肪酶的可逆和选择性抑制剂可缓解多发性硬化症.
摘要:单酰基甘油脂酶(magl)是负责内源性大麻素2-花生四烯酸甘油酯(2-Ag)失活的酶.magl抑制剂在几种疾病模型中均具有镇痛和组织保护作用.然而,迄今为止描述的几种有效且选择性的magl抑制剂不可逆地阻断了该酶,并且这可能导致药理学耐受性.因此,还需要其他类别的magl抑制剂来验证该酶是否可作为治疗靶标.此处我们报告一个有效的,选择性,和可逆的抑制剂magl(ic 50 = 0.18μ中号),它是体内活性和改善多发性硬化(ms)的小鼠模型的临床进展,而不引起不希望的cb 1介导的副作用.这些结果支持了对magl作为ms治疗靶标的兴趣.
DOI:10.1002/anie.201407807

专利信息

专利号:US-6693091-B2
优先权日:2002-03-29
标 题 :Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies
发明人：STROMGAARD KRISTIAN; SUEHIRO MAKIKO; NAKANISHI KOJI
权利人:UNIV COLUMBIA
摘要:A compound having the structure: n wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 3 is H or OH; n wherein R 4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and n wherein at least one of R 1 , R 2 , R 3 , or R 4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety. Optically pure enantiomers and salts of the compound are also described. Also, the synthesis of the compound, and uses of the compound, such as in a method for detecting the localization of, or identifying, receptors, enzymes or other targets, whether in a cell or in a subject.

专利号:US-5561143-A
优先权日:1995-01-25
标题:Aliphatic amino bis-aryl squalene synthase inhibitors
发明人：GRONEBERG ROBERT A; REGAN JOHN R; NEUENSCHWANDER KENT W; SCOTESE ANTHONY C
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:US-4411912-A
优先权日:1978-02-16
标 题 :Insecticidal isovaleric acid esters
发明人：HENRICK CLIVE A; GARCIA BARBARA A
权利人:ZOECON CORP
摘要:Esters and thiolesters of amino acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions for the control of pests.

专利号:US-5494918-A
优先权日:1991-03-08
标题 :Multicyclic tertiary amine polyaromatic squalene syntase inhibitors
发明人：NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:US-11535647-B2
优先权日:2018-09-14
标题 :Peptide purification method using sulfonate compound
发明人：MATSUYAMA KEISUKE; YAMAMOTO KENICHIRO; MURAKAMI SAYOKO
权利人:NAGASE & CO LTD
摘要:A method for purifying a target peptide may include mixing a peptide product obtained through a peptide synthesis with a solvent in the presence of a sulfonic acid compound to obtain a solid; and performing a solid-liquid separation to collect the solid.

专利号:US-5534532-A
优先权日:1993-05-21
标题 :Aliphatic amino bis-aryl squalene synthase inhibitors
发明人：GRONEBERG ROBERT A; REGAN JOHN R; NEUENSCHWANDER KENT W; SCOTESE ANTHONY C
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.