CAS: 315-72-0; 2-[4-(3-Benzo[b][1]Benzazepin-11-Ylpropyl)Piperazin-1-Yl]Ethanol

上下游产品

para-tert-butylphenol 2,4-di-tert-Butylphenolpropyl)-8H-dibenzoxadiazoloazepine 1-oxide8-(3-4-(2-hydroxyethyl)piperazinylpropyl)-8H-dibenz1oxa2,5diazolo3,4-dazepine 1-oxide

📜亚氨基芪置于potassium Carbonate,三辛基甲基溴化铵,Sodium Iodide体系中,用 甲苯,乙腈 用作溶剂,化学反应 24.0H,反应生成奥匹哌醇
参考文献:手性 Sigma-1 受体放射性配体的两种对映异构体的合成和表征:(S)-(+)-和 (R)-(-)-[18F]Fbfp
标题:手性 Sigma-1 受体放射性配体的两种对映异构体的合成和表征:(S)-(+)-和 (R)-(-)-[18F]Fbfp
摘要:外消旋的 [ 18 F]Fbfp ([ 18 F] 1 ) 被证明是一种有效的σ 1受体放射性示踪剂,具有出色的成像特性.合成并表征了未标记化合物( S )-和( R )-1的纯对映异构体和相应的碘鎓叶立德前体.两种对映异构体 ( S )-1和 ( R )-1对σ 1 受体表现出相当高的亲和力,对σ 2受体表现出相当高的选择性.Ca 2+荧光测定表明(R)-1表现为拮抗剂,( S )-1表现为σ 1受体的激动剂.18 F 标记的对映体 ( S )-和 ( R )-[ 18 F] 1从相应的对映体纯碘鎓叶立德前体获得 > 99% 的对映体纯度,放射化学产率为 24.4% +/-2.6%,摩尔活性为 86-214 Gbq/微摩尔.在 Icr 小鼠中 ( S )-和 ( R )-[ 18 F] 1表现出相当高的脑摄取,脑血比,体内在大脑和周围器官中的稳定性和结合特异性.在大鼠的微正电子发射断层扫描
Doi:10.1016/j.Cclet.2022.03.099

专利信息

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof

专利号:US-8138174-B2
优先权日:2007-01-10
标 题:Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Compounds with a combination of cannabinoid CB 1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds, methods for preparing these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing these compositions are disclosed. Uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders are disclosed. n In at least one embodiment, the invention relates to compounds of the general formula (1): n nwherein the substitutents have the definitions given in the specification.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles