CAS: 2867-59-6; 3-Aminobutan-1-Ol

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CAS号2835-82-7 3-氨基丁酸 | CAS号5303-65-1 3-氨基丁酸乙酯 | CAS号126121-40-2 METHYL 2-((1S,4... | CAS号626-34-6 3-氨基巴豆酸乙酯 | CAS号102222-60-6 | CAS号590-90-9 4-羟基-2-丁酮 | CAS号86260-82-4 5-ethoxy-3-meth... | CAS号57598-33-1 2-(2-甲氧基苯基)-4,4... | CAS号174743-89-6 4-羟基-2-丁基氨基甲酸苄酯 | CAS号2617-98-3 5,6,7,8-四氢-2-甲基喹啉

4-羟基-2-丁酮置于还原型辅酶ⅰ体系中,用 Aq. Buffer 用作溶剂,化学反应生成3-氨基正丁醇
参考文献:使用氧化还原中性双酶级联反应对仲醇进行不对称胺化反应
标题:使用氧化还原中性双酶级联反应对仲醇进行不对称胺化反应
摘要:需要从简单的非手性化合物合成光学纯分子的多酶级联方法.在此,通过使用醇脱氢酶和新开发的胺脱氢酶成功构建了外消旋仲醇不对称胺化为相应手性胺的辅因子自足级联方案.两种酶的相容性和相同的辅因子依赖性导致在单罐合成中形成了巧妙的原位辅因子回收系统.人工氧化还原-中性级联过程使外消旋仲醇转化为对映体纯胺,具有相当大的转化率(高达94%),对映体过量超过99%,而仅以氨为代价.
Doi:10.1002/cctc.201500785

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-2025034607-A1
优先权日:2021-12-03
标题 :Process of Synthesizing (R)-3-aminobutan-1-ol
发明人：BOBKO MARK; FUERST DOUGLAS; MORGAN CHRISTOPHER
权利人:VIIV HEALTHCARE CO
摘要:The present invention relates to an aminotransaminase useful in the synthesis of (R)-3-aminobutan-1-ol (RABO). The present invention also provides a process of preparing (R)-3-aminobutan-1-ol (RABO) with the disclosed aminotransaminase.

专利号:US-8877977-B2
优先权日:2011-11-25
标题 :Synthesis of polyalkylenepolyamines having a low color index by homogeneously catalyzed alcohol amination in the presence of hydrogen
发明人：STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO
权利人:STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO; BASF SE
摘要:Process for the preparation of polyalkylenepolyamines by homogeneously catalyzed alcohol amination, in which aliphatic amino alcohols are reacted with one another or aliphatic diamines or polyamines are reacted with aliphatic diols or polyols with the elimination of water in the presence of a homogeneous catalyst and in the presence of hydrogen gas. Polyalkylenepolyamines obtainable by such processes and polyalkylenepolyamines comprising hydroxy groups, secondary amines or tertiary amines. Uses of such polyalkylenepolyamines as adhesion promoters for printing inks, adhesion promoters in composite films, cohesion promoters for adhesives, crosslinkers/curing agents for resins, primers for paints, wet-adhesion promoters for emulsion paints, complexing agents and flocculating agents, penetration assistants in wood preservation, corrosion inhibitors, immobilizing agents for proteins and enzymes.

专利号:US-9365587-B2
优先权日:2008-12-11
标 题:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
发明人：YOSHIDA HIROSHI; TAODA YOSHIYUKI; JOHNS BRIAN ALVIN; KAWASUJI TAKASHI; NAGAMATSU DAIKI
权利人:SHIONOGI & CO; VIIV HEALTHCARE CO
摘要:The invention is a process for the preparation of a compound of the following formula (I): n nwherein R is —CHO, —CH(OH) 2 or —CH(OH)(OR 4 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R x is H, halogen or R 2 —X—NR 1 —C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.

专利号:WO-2013076053-A1
优先权日:2011-11-25
标题:Synthesis of polyalkylene polyamines with low color index by homogeneously catalyzed alcohol amination in the presence of hydrogen
发明人：STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO
权利人:BASF SE; STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO
摘要:The invention relates to a method for the production of polyalkylene polyamines by homogeneously catalyzed alcohol amination, wherein aliphatic alkanolamines are reacted with each other or aliphatic diamines or polyamines are reacted with aliphatic diols or polyols in the presence of a homogeneous catalyst while eliminating water and in the presence of hydrogen gas. The invention further relates to polyalkylene polyamines, which can be obtained by said methods, and to polyalkylene polyamines which contain hydroxyl groups, secondary amines or tertiary amines. The invention finally relates to uses of said polyalkylene polyamines as adhesion promoters in inks, adhesion promoters in composite films, cohesion promoters in adhesives, cross-linkers/hardeners for resins, primers for paints, wet adhesion promoters for dispersion paints, complexing agents and flocculants, penetration auxiliaries for use in wood preservation, corrosion inhibitors, and immobilization agents of proteins and enzymes.

专利号:EP-2321225-B1
优先权日:2008-08-13
标题:Use of a weakly ionic acrylic polymer in the synthesis of precipitated calcium carbonate
发明人：GUILLOT MURIELLE; KENSICHER YVES
权利人:COATEX SAS
摘要:The invention consists of the use, in a process for manufacturing a mineral material including in particular a precipitated calcium carbonate, of a polymer constituted of at least one vinyl monomer chosen from acrylic acid, methacrylic acid, acrylamide, methacrylamide or a cationic monomer, or mixtures thereof, and of at least one nonionic monomer. The use of this polymer makes it possible to reduce the carbonation time of the PCC, without however impairing its crystallographic structure and its granulometric characteristics.