2,5-二氟甲苯置于氯体系中,化学反应生成2,5-二氟苯甲醛 参考文献:Inukai; Maki,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1956,Vol. 59,P. 1160 标题:Inukai; Maki,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1956,Vol. 59,P. 1160
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
专利号:US-7759471-B2 优先权日:2005-10-31 标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
专利号:US-9481680-B2 优先权日:2014-03-20 标题 :Process for the preparation of key intermediates of omarigliptin 发明人:DE LUCCHI OTTORINO; ROSSO ENRICO; ZARAMELLA SIMONE; TARTAGGIA STEFANO 权利人:F I S —FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A 摘要:An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) n nwherein R 1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV)n n nby an amination reaction to a compound of formula (III),n n nwhich is then protected to provide a compound of formula (II),n n nwhich is then alkylated to provide the compound of formula (I).
专利号:US-2007100138-A1 优先权日:2005-10-31 标题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
专利号:US-2007100136-A1 优先权日:2005-10-31 标题:Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
专利号:EP-2001896-A2 优先权日:2006-03-23 标 题 :Monomer compositions for the synthesis of rna, methods of synthesis, and methods of deprotection
参考标题:One-Pot Synthesis Of Substituted Indolo[1,2-A]Quinolines Under Transition-Metal-Free Conditions 作者:Adisak Thanetchaiyakup,Hassayaporn Rattanarat,Nutthawat Chuanopparat,Paiboon Ngernmeesri |发布日期:2018.3 摘要:A Simple And Efficient One-Pot Synthesis Of Substituted Indolo[1,2-A]Quinolines Under Transition-Metal-Free Conditions Has Been Developed. When 2-Fluorobenzaldehyde Was Treated With Substituted 2-Methylindoles In The Presence Of Cs2Co3, The Desired Products Were Typically Obtained In Good To Excellent Yields. This Reaction Sequence Involves A Nucleophilic Aromatic Substitution And A Knoevenagel Condensation
合成参考文献
摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 31. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 8. 摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 44.