CAS: 2620-44-2; 5-Nitrobenzo[d][1,3]Dioxole

该化合物是有机化合物,其独特结构特征包括一种苯二氮新诺明,在6号位置以硝基化合物组替代,该化合物一般为灰黄色至浅褐色固态,以其芳香特性著称,在有机溶剂中溶解,但水溶性有限.硝基化合物的存在有助于其再活性,使其有可能成为各种化学反应,包括硝化和减少过程的候选物.此外,6-nitro-1.3-benzodooxole可以用于其他化学化合物的合成,并展示生物活动,尽管具体应用可能有所不同.安全数据表明,应谨慎处理该化合物,因为硝基化合物可能具有危险性.

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上下游产品

CAS号274-09-9 1,2-亚甲二氧基苯 | CAS号94839-07-3 3,4-(亚甲基二氧基)苯硼酸 | CAS号7228-38-8 5-氯-1,3-苯并二氧杂环戊 | CAS号3162-29-6 3',4'-(亚甲基二氧)苯乙酮 | CAS号14268-66-7 3,4-亚甲二氧基苯胺 | CAS号75-11-6 二碘甲烷 | CAS号3316-09-4 4-硝基儿茶酚 | CAS号94-53-1 胡椒酸 | CAS号133-03-9 EPISESAMIN | CAS号120-57-0 胡椒醛 | CAS号39835-14-8 2-羟基-4-硝基苯腈 | CAS号636-93-1 5-硝基愈创木酚 | CAS号130400-94-1 3-hydroxy-4-iso... | CAS号3316-09-4 4-硝基儿茶酚 | CAS号7251-09-4 4-氨基-2-甲氧基苯腈 | CAS号101084-96-2 2-甲氧基-4-硝基苯甲腈 | CAS号14268-66-7 3,4-亚甲二氧基苯胺 | CAS号121-88-0 2-氨基-5-硝基苯酚 | CAS号13067-19-1 N-(苯并[d][1,3]二氧... | CAS号59856-06-3 N-(2,3-二氢-1H-茚-...

合成工艺路线路线简述

    📜胡椒环置于六氟异丙醇,四丁基亚硝酸铵体系中,用 乙腈 用作溶剂,化学反应 0.83H,以28%的收率获得1,2-亚甲基双氧-4-硝基苯
    参考文献:亚硝酸盐电化学硝化
    标题:亚硝酸盐电化学硝化
    摘要:芳烃,苯酚和苯胺衍生物的硝化是通过使用廉价的石墨电极将亚硝酸盐作为安全硝基源电化学氧化为no 2 /n 2 O 4来完成的.乙腈中化学计量的 1,1,1-3,3,3-六氟异丙-2-醇 (Hfip) 通过溶剂控制可显着提高产率.该反应具有可扩展性,已论证了 20 个实例,产率高达 88%.
    Doi:10.1002/cssc.202102053

    海关参考信息

    专利信息


    专利号:US-2015038591-A1
    优先权日:2002-05-31
    标 题:Compounds, compositions and methods for the treatment of tauopathies
    发明人:SNOW ALAN D; CAM JUDY A; CASTILLO GERARDO; HU QUBAI; LAKE THOMAS
    权利人:PROTEOTECH INC
    摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of tauopathies, such as Alzheimer's disease and Parkinson's disease, and the manufacture of medicaments for such treatment.

    专利号:US-7919530-B2
    优先权日:2002-05-31
    标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies
    发明人:ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
    权利人:PROTEOTECH INC
    摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

    专利号:US-7601876-B2
    优先权日:2002-05-31
    标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
    发明人:SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE
    权利人:PROTEOTECH INC
    摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

    专利号:EP-4245856-B1
    优先权日:2022-03-15
    标题 :Synthesis of functional unspecific peroxidases using a non-fungal eukaryotic cell-free system
    发明人:WALTER RUBEN; KUBICK STEFAN; ZEMELLA ANNE
    权利人:FRAUNHOFER GES FORSCHUNG

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    专利号:US-5874443-A
    优先权日:1995-10-19
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 245.
    摘要:van der Puyl, V.; Shenvi, R. A., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 652.
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