CAS: 2463-84-5; Dicapthon

该化合物是属于有机磷化合物类别的化学化合物,主要被确认为农药,特别是在农业环境中作为杀虫剂和杀虫剂使用,Dicapthon对人类和非目标生物体具有中等毒性,需要小心处理和应用;该化合物的特点是它能够破坏虫害...

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2-chloro-4-nitrophenol dimethyl chlorothiophosphate sodium salt of 2-chloro-4-nitrophenolO,O-dimethyl O-phenyl phosphorothioate O,O,O-trimethylthiophosphate 2-chloro-4-nitrophenol Monothiophosphorsaeure-O,O-dimethyl-O-(2,4,5-trichlor-phenylester)

合成工艺路线路线简述

    📜2-氯-4-硝基苯酚钠,二甲基硫代磷酰氯 反应生成异氯磷
    参考文献:Jentzsch,R. Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1977,Vol. 319,P. 862-870
    标题:Jentzsch,R. Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1977,Vol. 319,P. 862-870

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:WO-2021009026-A1
    优先权日:2019-07-12
    标 题 :Methyl 2-[(4-methoxyimino-tetralin-6-yl]prop-2-enoate derivatives, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1h-isobenzofurane and indane analogues thereof, and similar compounds, as agrochemical fungicides
    发明人:WEISS MATTHIAS; WILLIAMS SIMON; RENDINE STEFANO; BOU HAMDAN FARHAN; HOFFMAN THOMAS; QUARANTA LAURA
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:Compounds of formula (I): (Formula (I)) Formula (I) encompasses e.g. tetraline, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1H-isobenzofurane and indane derivatives. The compounds of formula (I) are useful as a pesticides, especially as fungicides. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 53 to 78; examples 1 to 10; table T1; compounds 1.1 to 1.54; examples A and B). Preferred compounds are e.g.: Methyl (E)-3-methoxy-2-[(4E)-4-methoxyimino-7-methyl-tetralin-6- yl]prop-2-enoate (example 2; compound 1.6 of table T1): (Formula (A)). Methyl (E)-3-methoxy-2-[(4Z)-4-methoxyiminoisochroman-6-yl]prop-2- enoate (example 6; compound 1.39 of table T1): (Formula (B))

    专利号:WO-2024022910-A1
    优先权日:2022-07-26
    标题 :1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds as pesticides
    发明人:WEISS MATTHIAS; JEANGUENAT ANDRE; KILARU JAGADEESH PRATHAP; MUEHLEBACH MICHEL; SCARBOROUGH CHRISTOPHER CHARLES; STOLLER ANDRé; SUESSE LARS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to compounds of formula (I) wherein: X is O or S; Q is Q a or Q b as pesticides and insecticides. Preferred compounds are e.g. 1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds. An exemplary compound is e.g. 1-[(1S)-1-[2-(6-cyanopyrimidin-4-yl) -1,2,4-triazol-3-yllethyll-3-[2,4-dichloro-5-(trifluoromethyl)phenyllurea (example E1; compound P1). The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof.

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    主要参考文献


    1: Liman R. Mutagenicity and genotoxicity of dicapthon insecticide. Cytotechnology. 2014 Oct;66(5):741-51. doi: 10.1007/s10616-013-9623-x. Epub 2014 Jan 31.
    2: Baughman RG, Hall GB. Two organophosphorus pesticides: methyl parathion and dicapthon. Acta Crystallogr C Struct Chem. 2014 Oct;70(Pt 10):975-7. doi: 10.1107/S2053229614020233. Epub 2014 Sep 28.

    合成参考文献


    摘要:Journal of Agricultural and Food Chemistry., 11(91), 1963
    摘要:World Review of Pest Control., 3(28), 1964
    摘要:Toxicology and Applied Pharmacology., 2(88), 1960 []
    摘要:Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London: Williams and Wilkins, 1982., p. 360
    摘要:U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, National Institute for Occupational Safety Health. Registry of Toxic Effects of Chemical Substances (RTECS). National Library of Medicine's current MEDLARS file., p. 85/8403
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