CAS: 2058-52-8; 8-Chloro-6-(4-Methylpiperazin-1-yl)Benzo[b][1,4]Benzothiazepine

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CAS号3159-04-4 2-氯二苯并[b,f]的[1,... | CAS号2770-11-8 4'-氯-2-氨基-二苯醚 | CAS号109-01-3 N-甲基哌嗪 | CAS号13745-88-5 2,11-dichloro-d... | CAS号37750-29-1 2-氨基-4'-氯二苯硫醚 | CAS号626-58-4 4-甲基哌啶 | CAS号30690-45-0 2-chlorodibenzo...

📜2-氯-二苯并[b,F][1,4]硫氮杂环庚烷-11(10H)-酮置于n,N-二甲基苯胺,三氯氧磷体系中,用 Xylene 用作溶剂,化学反应 10.0H,反应生成氯噻平
参考文献:在11-Stellung氨基取代基dibenzo [b,F]-1,4-Thiazepine和-Oxazepine中使用über.9. Mitteilungübersiebengliedrige杂环†
标题:在11-Stellung氨基取代基dibenzo [b,F]-1,4-Thiazepine和-Oxazepine中使用über.9. Mitteilungübersiebengliedrige杂环†
摘要:在11-氨基取代的二苯并[b,F]-1,4-噻氮平和二苯并[b,F]-1,4-氧杂氮平系列iii中发现了抗精神病药.它们可以通过亚氨基氯化物vi的氨解和/或尿素ii的bischler-Napieralski用pocl 3闭环合成.
Doi:10.1002/hlca.19670500131

专利信息

专利号:US-9884844-B2
优先权日:2012-12-31
标 题:Heterocyclic compounds and methods of use thereof
发明人：FANG QUN KEVIN; CAMPBELL UNA; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

专利号:US-2023241088-A1
优先权日:2022-01-17
标 题 :Composition for preventing or treating lung cancer comprising ortho-topolin riboside as active ingredient
发明人：CHOI HYUNG-KYOON; LEE HWANHUI
权利人:CHUNG ANG UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION
摘要:The present disclosure relates to a composition for preventing or treating lung cancer, including ortho topolin riboside (oTR) as an active ingredient, wherein oTR showed the highest cytotoxicity among all tested compounds against NSCLC cells, oTR reduced synthesis of amino acid and pyrimidine as well as glycolytic function in NSCLC cells and xenograft tumors.

专利号:US-9670230-B2
优先权日:2012-11-29
标题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; JONES PHILIP
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

专利号:US-11332462-B2
优先权日:2012-02-08
标 题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; CAMPBELL UNA; HANANIA TALEEN G; SHAO LIMING
权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC
摘要:Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

专利号:US-3150124-A
优先权日:1962-03-16
标题:Synthesis of kinetin glycosides
发明人：GEORGE SVARNAS; HERMAN RUTNER
权利人:GEORGE SVARNAS; HERMAN RUTNER

专利号:WO-2025118034-A1
优先权日:2023-12-06
标题 :Compounds active at the serotonergic 5-ht2a receptor
发明人：JORGENSON WILLIAM; TAN JINLONG; WHISH LACHLAN; BANISTER SAMUEL
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.